Abstract
The metabolism of the apolipoproteins covers a very broad subject area. I would like to discuss it, in the main, from the somewhat narrower focus of VLDL catabolism in the rat. I would like to point out that it may be rather artificial to consider apolipoprotein metabolism apart from lipoprotein metabolism, but it is becoming increasingly apparent that apolipoproteins may also have a life of their own. In the beginning, of course, there is DNA and messenger RNA which code for the primary sequence of the apolipoproteins and, after signal peptide cleavage, these traverse the cisternae of the endoplasmic reticulum, ending up in the Golgi where much of the final assembly of VLDL takes place, as seen by electron microscopic studies.1 The liver is the main organ of lipoprotein synthesis, and probably also of catabolism, and it can synthesize all of the known major apolipoproteins: A-I, A-II, A-IV, B, C-I, C-II, C-III, and E. The small intestinal mucosal cells secrete far less apolipoproteins, but the work of Wu and Windmueller2 has shown that about half of the plasma A-I, and about two-thirds of apo A-IV, are derived from the intestine, which secretes VLDL and HDL as well as chylomicrons.3 There have been some recent exciting developments bearing on the question of the synthesis of different apolipoprotein isoforms, such as those of apo A-I4,5 and on the involvement of tissues other than liver and intestine which I will only mention briefly.
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© 1985 Plenum Press, New York
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Marsh, J.B. (1985). Metabolism of Apolipoproteins and the Metabolic Heterogeneity of Apo B in the Rat. In: Kritchevsky, D., Holmes, W.L., Paoletti, R. (eds) Drugs Affecting Lipid Metabolism VIII. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2459-1_8
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DOI: https://doi.org/10.1007/978-1-4613-2459-1_8
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