Chemotherapy for G3-pTis Carcinoma of the Bladder
In recent years perhaps one of the main contributions towards rational management of urothelial malignancy has been the increasing recognition of carcinoma insitu and the acceptance of its significance as an early phase in the development of invasive tumor. The disease is a progression from epithelial atypia and although bladder is the commonest site the process is really a field change with any part of the urothelium liable to be affected and of particular significance is the epithelium lining the prostatic ducts. The nature of the lesions is against successful control by endoscopic resection or diathermy and usually, although not always, radiotherapy is ineffective whilst radical surgery cannot seriously be advanced as routine primary treatment.
KeywordsToxicity Methotrexate Cyclophosphamide Mitomycin Adriamycin
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