Abstract
Epidemiologic and genetic studies on the evolution of cardiovascular disease in man have repeatedly supported the importance of plasma cholesterol levels in the pathogenesis of coronary atherosclerosis (1–4). These studies also emphasize the importance of distinguishing the cholesterol content of the lipoprotein fractions very low density (VLDL), low density (LDL) and high density lipoproteins (HDL). A close correlation between increased levels of LDL known to contain the major part of the transported cholesterol, and the risk of developing coronary atherosclerosis was found (2,5). HDL, on the other hand, appeared to be negatively correlated with the occurrence of coronary heart disease (6–9).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
McGee, D., and T. Gordon. April 1976. The Framingham Study: the results of the Framingham Study applied to four other U.S.-based epidemiologic studies of cardiovascular disease. Section 31, DHEW Public No. (NIH) 76-1083
Kannel, W.,B. W.P. Castelli, T. Gordon, and P. McNamara. 1971. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham Study. Ann. Intern. Med. 74: 1–12.
Keys, A. 1975. Coronary heart disease - the global picture. Atherosclerosis 22: 149–192.
Gordon, T., M. Carcia-Palmieri, A. Kagan, W.B. Kannel, and Scherffman, J. 1974. Differences in coronary heart disease in Framingham, Honolulu and Puerto Rico. J. Chronic. Dis. 27: 329–344.
Walton, K.W . 1975. Pathogenic mechanism in atherosclerosis. Amer. J. Cardiol. 35: 542–558.
Castelli, W.P., J.T. Doyle, T. Gordon, C.G. Hames, M.C. Hjortland, S.B. Hulley. A. Kagan, and W.J. Zukel, 1977. HDL-cholesterol and other lipids in coronary heart disease. Circulation 55: 767–772.
Gordon, T., W.P. Castelli, M.C. Hjortland, W.B. Kannel, and T. Dawber. 1977. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Amer. J. Med. 62: 707-714.
Miller, N.E., O.H. Forde, D.S. Thelle, and O.D. Mjos. 1977. The Tromsø heart-study- High-density lipoprotein and coronary heart-disease. A prospective case-control study. Lancet i: 965–967
Salel, A.F., A. Fong, R. Zelis, R.R. Miller, N.O. Borhani, and D.T. Mason. 1977. Accuracy of numerical coronary profile. Correlation of risk factors with ar. teriographically documented severity of atherosclerosis. New Engl. J. Med. 296: 1447–1450.
Levine, J., S. Morgenstern, and D. VlasteTica. 1967. Direct Liebermann-Burchard method for serum cholesterol. Technicon Symp. 1: 25.
Burstein, M., and H.R. Scholnik. 1971. Isolation of lipoproteins from human serum by precipitation with polyanions and divalent cations. Prot. Biol. Fluids 19: 21–27.
Riesen, W.F., R.C. Mordasini, and G.W. Middelhoff. 1978. Quantitation of the two major apoproteins of human high density lipoproteins by solid phase radioimmunoassays. FEBS letters 91: 35–39.
Mordasini, R., and W.F. Riesen. 1980. Electroimmunoassay and radioimmunoassay for the quantitation of high density apolipoproteins A-I and A-II. J. Clin. Chem. Clin. Biochem. J. Clin. Chem. Clin. Biochem. 18: 917–920.
Rifkind, B.M., I. Tamir, G. Heiss5 R.B. Wallace, and H.A. Tyroler. 1979. Distribution of high density and other lipoproteins in selected LRC prevalence study populations: a brief survey. Lipids 14: 105–112.
Stein, Y., M.C. Glangeau, M. Fainaru, and O. Stein. 1975. The removal of cholesterol from aortic smooth muscle cells in culture and Landschutz ascites cells by fractions of human high density apolipoprotein. Biophys. Acta 380: 106–118.
Carew, T.E., S.B. Hayes, F. Koshinsky5 P. Steinberg. 1976. A mechanism by which high density lipoproteins may slow the atherogenic process. Lancet: 1315–1317.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Riesen, W.F., Mordasini, R.C., Sepulcri, F.D., Oetliker, O.H. (1985). On the Development of Apoprotein and Lipid Levels throughout Childhood. In: Halpern, M.J. (eds) Lipid Metabolism and Its Pathology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2445-4_26
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2445-4_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9486-3
Online ISBN: 978-1-4613-2445-4
eBook Packages: Springer Book Archive