Bile Acid Metabolism in Hyperlipoproteinemias

  • Tatu A. Miettinen

Abstract

Cholesterol is eliminated from the body mainly via the gastrointestinal tract into feces as cholesterol itself or after hepatic conversion to cholic acid and chenodeoxycholic acid as these primary bile acids or as their bacterial transformation products. The magnitude by which cholesterol elimination takes place as bile acids can be measured by quantitation of fecal bile acids or by the isotope dilution technique. In the present paper some parameters of bile acid metabolism are dealt with in different hyperlipoproteinemias mainly on the basis of our own experience on fecal bile acid measurements. The capacity to produce bile acids has been tested after administration of cholestyramine. In a recent review a computerized analysis has been performed on reported fecal steroids of individual subjects with different hyperlipoproteinemias.1

Keywords

Cholesterol Obesity Acid Value Choles Thyroxine 

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References

  1. 1.
    Sodhi U.S., Kudchodkar B.J. & Mason D.T. Adv. Lipid. Res. 1980: 17: 107.PubMedGoogle Scholar
  2. 2.
    Miettinen T.A., Pelkonen R., Nikkila E.A. & Heinonen O. Acta Med. Scand. 1967: 182: 645.PubMedCrossRefGoogle Scholar
  3. 3.
    Miettinen T.A. 1973. In Bile acids. Eds. P.P. Nair & D. Kritchevsky. Plenum Press Vol. 2: 191.Google Scholar
  4. 4.
    Miettinen T.A. Arch. Surgery 1978: 113: 45.Google Scholar
  5. 5.
    Miettinen T.A. 1975. In Handbook of experimental pharmaco-logy. Pharmacology of hypolipidemic agents. Ed. D. Kritchevsky, Springer-verlag, Berlin-Heidelberg- New York, p. 109.Google Scholar
  6. 6.
    Moutafis C.D. & Myant N.B. Clin. Sci. 1969: 37: 443; Moutafis C.D., Simons L.A., Myant N.B., Adams P.W.R. & Wynn V. Atherosclerosis 1977: 26: 329.Google Scholar
  7. 7.
    Grundy S.M., Ahrens E.H. Jr. & Salen G. J. Lab. Clin. Med. 1971: 78: 94.PubMedGoogle Scholar
  8. 8.
    Carter G.A., Connor W.E., Bhattacharyya A.K. & Lin D.S. J. Lipid. Res. 1979: 20: 66.PubMedGoogle Scholar
  9. 9.
    Hellstrom K. & Einarsson K. Clinics in Gastroenterology 1977: 6: 103.PubMedGoogle Scholar
  10. 10.
    Miettinen T.A. Circulation 1971: 44: 842.PubMedGoogle Scholar
  11. 11.
    Miettinen T.A. 1972. In Bile acids in human diseases. Ed. P. Back & W. Gerok, F.K. Schattauer Verlag, Stuttgart- New York, p. 117.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Tatu A. Miettinen
    • 1
  1. 1.Second Department of MedicineUniversity of HelsinkiFinland

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