Tumorcidal Activation and Kinetics of Ectoenzyme Production Elicited by Synthetic Polyanions
Polyanionic compounds have been shown to exert a profound influence on the immune response (1,2). These compounds are capable of modulating responses of T lymphocytes, B lymphocytes, and macro-phages when administered via the appropriate route and at the appropriate time. They have been shown to enhance and suppress specific and non-specific immune responsiveness (3). Pyran, a polyanionic compound composed of maleic anhydride and divinyl ether, exerts its effect on T cells, B cells, and macrophages (1). The fact that pyran can “activate” macrophages to nonspecifically kill tumor cells has been the subject of a great deal of investigation. The role of activated macrophages as a mechanism of immunopotentiator-mediated anti-tumor activity has been established. However, little information exists with respect to the factors which control macrophage differentiation to the activated state. Certainly, significant differences in the properties of normal, elicited and activated macrophage have been demonstrated. However, the signals that trigger the events which lead to these states are unknown.
KeywordsToxicity Benzene Vinyl Anhydride Hydride
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