Abstract
The past several decades have witnessed major advances in the practice of therapeutics. It is now recognized that the nature, duration, and intensity of drug action are dependent not only on the intrinsic properties of the drug but also on the interaction with the host to whom the drug is being administered. Although research has been proceeding at a rapid rate in adult medicine, developments in drug therapy during pregnancy, the perinatal period, and in the neonate are lagging far behind the other disciplines. This is because research in humans during pregnancy is limited by ethical and practical considerations. Therefore, present drug use in pregnancy is based on cautious empiricism, with therapeutic misadventures acting as warning signals.
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References
Wood AJJ, Carr K, Vestal RE, et al: Direct measurement of the propranolol bioavailability during accumulation to steady-state. Br J Clin Pharmacol 6: 345–350, 1978
Huet M, LeLorier J, Pomier G, et al: Bioavailability of lidocaine in normal volunteers and cirrhotics. Gastroenterology 75: 968A, 1978
Hill N, Antman EM, Green LH, et al: Intravenous nitroglycerin—a review of pharmacology, indications, therapeutic effects and complications. Chest 79: 69–76, 1981
Kostenbauder HB, Rapp RP, McGovern JP, et al: Bioavailability and single-dose pharmacokinetics of intramuscular phenytoin. Clin Pharmacol Ther 18: 449–456, 1975
Wilder BJ, Serrano EE, Ramsey E, et al: A method of shifting from oral to intramuscular diphenylhydantoin administration. Clin Pharmacol Ther 16: 507–513, 1974
Davison JS, Davison MC, Hay DM: Gastric emptying time in late pregnancy and labour. J Obstet Gynaecol Br Commonw 77: 37–41, 1970
Gryboski WA, Spiro HM: The effect of pregnancy on gastric secretion. N Engl J Med 255: 1131–1134, 1956
Krauer B, Krauer F: Drug kinetics in pregnancy. Clin Pharmacokinet 2: 167–181, 1977
Pirani BKK, Campbell DM, MacGillivray I: Plasma volume in normal pregnancy. J Obstet Gynaecol Br Commonw 80: 884–887, 1973
Katz R, Karliner JS, Resnik R: Effects of a natural volume overload state (pregnancy) on left ventricular performance in normal human subjects. Circulation 58: 434–441, 1978
Munnell EW, Taylor HC: Liver blood flow in pregnancy hepatic vein catheterization. J Clin Invest 26: 952–956, 1947
Krauer B, Krauer F, Hytten FE: Drug disposition and pharmacokinetics in the maternal-placental-fetal unit. Pharmacol Ther 10: 301–328, 1980
Appel GB, Neu HC: Gentamicin in 1978. Ann Intern Med 89: 528–538, 1978
Aronson JK: Clinical pharmacokinetics of digoxin 1980. Clin Pharmacokinet 5: 137–149, 1980
Robertson EG: Physiologic adjustments in pregnancy: Water metabolism. Clin Obstet Gynecol 2: 431–440, 1975
Perucca E, Crema A: Plasma protein binding of drugs in pregnancy. Clin Pharmacokinet 7: 336–352, 1982
Reboud P, Groulade J, Groslambert P, et al: The influence of normal pregnancy and the postpartum state of plasma proteins and lipids. Am J Obstet Gynecol 86: 820–828, 1963
Wood M, Wood AJJ: Changes in plasma drug binding and α1-acid glycoprotein in mother and newborn infant. Clin Pharmacol Ther 29: 522–526, 1981
Perucca E, Ruprah M, Richens A: Decreased serum protein binding of diazepam and valproic acid in pregnant women. Br J Clin Pharmacol 12: 276P, 1981
Chen SS, Perucca E, Lee JN, et al: Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy. Br J Clin Pharmacol 13: 547–552, 1982
Dean M, Stock B, Patterson RJ, et al: Serum protein binding of drugs during and after pregnancy in humans. Clin Pharmacol Ther 28: 253–261, 1980
Dvorchik BH: Drug disposition during pregnancy. Biol Res Preg 3: 129–137, 1982
Davis M, Simmons GJ, Dordoni B, et al: Induction of hepatic enzymes during normal human pregnancy. J Obstet Gynaecol Br Commonw 81: 690–695, 1973
Davison JM, Hytten FE: Glomerular filtration during and after pregnancy. J Obstet Gynaecol Br Commonw 81: 588–595, 1974
Zaske DE, Cipolle RJ, Strate RG, et al: Rapid gentamicin elimination in obstetric patients. Obstet Gynecol 56: 559–564, 1980
Kubacka RT, Johnstone HE, Tan HSI, et al: Intravenous ampicillin pharmacokinetics in the third trimester of pregnancy. Ther Drug Monit 5: 55–60, 1983
Nau H, Kunz W, Egger HJ, et al: Anticonvulsants during pregnancy and lactation—transplacental, maternal and neonatal pharmacokinetics. Clin Pharmacokinet 7: 508–43, 1982
Lander CM, Edwards VE, Eadie MJ, et al: Plasma anticonvulsant concentrations during pregnancy. Neurology (Minneap) 27: 128–131, 1977
Eadie MJ, Lander CM, Tyrer JH: Plasma drug level monitoring in pregnancy. Clin Pharmacokinet 2: 427–436, 1977
Peabody JL: Transcutaneous oxygen measurement to evaluate drug effects. Clin Perinato16: 109–121, 1979
Juchau MR, Chao ST, Omiecinski CJ: Drug metabolism by the human fetus. Clin Pharmacokinet 5: 320–339, 1980
National Foundation-“March of Dimes”: Facts. White Plains, New York, 1979
Wilson JG: Embryotoxicity of drugs in man, in Wilson JG, Fraser FC (eds): Handbook of Teratology, vol 1. New York, Plenum Press, 1977, p 309
Bleyer WA, Au WYW, Lang WA, et al: Studies on the detection of adverse drug reactions in the newborn. I. Fetal exposure to maternal medication. JAMA 213: 2046–2050, 1970
Yager JW: Congenital malformations and environmental influence: The occupational environment of the laboratory worker. J Occup Med 15: 724–728, 1973
Stern L: In vivo assessment of the teratogenic potential of drugs in humans. Obstet Gynecol 58: 3S–8S, 1981
Ballard PL, Ballard RA: Corticosteroids and respiratory distress syndrome: Status 1979, Pediatrics 63: 163–165, 1979
Petersen MC, Nation RL, Ashley JJ, et al: The placental transfer of betamethasone. Eur J Clin Pharmacol 18: 245–254, 1980
Harrigan JT, Kangos JJ, Sikka A, et al: Successful treatment of fetal congestive heart failure secondary to tachycardia. N Engl J Med 304: 1527–1529, 1981
Newburger JW, Keane JF: Intrauterine supraventricular tachycardia. J Pediatr 95: 780–786, 1979
Kerenyi TD, Gleicher N, Meller J, et al: Transplacental cardioversion in intrauterine supraventricular tachycardia and digitalis. Lancet 2: 393–395, 1980
Klein AM, Holzman IA, Austin EM: Fetal tachycardia prior to the development of hydrops. Attempted pharmacologic cardioversion: case report. Am J Obstet Gynecol 134: 347–348, 1979
Dumesic DA, Silverman NH, Tobias S, et al: Transplacental cardioversion of fetal supraventricular tachycardia with procainamide. N Engl J Med 307: 1128–1131, 1982
Gladstone GR, Hordorf A, Gersony WM: Propranolol administration during pregnancy: Effects on the fetus. J Pediatr 86: 962–964, 1975
Habib A, McCarthy JS: Effects on the neonate of propranolol administered during pregnancy. J Pediatr 91: 808–811, 1977
Bray RE, Boe RW, Johnson WL: Transfer of ampicillin into the fetus and amniotic fluid from maternal plasma in late pregnancy. Am J Obstet Gynecol 96: 938–942, 1966
Depp RC, Kind AC, Kirby WMM, et al: Transplacental passage of methicillin and dicloxacillin into the fetus and amniotic fluid. Am J Obstet Gynecol 107: 1054–1057, 970
Szeto HH, Mann LI, Ghaktharathsalan A, et al: Meperedine pharmacokinetics in the maternal-fetal unit. J Pharmacol Exp Ther 206: 448–459, 1978
Idanpaan-Heikkala JE, Jouppila JE, Poulakka, et al: Placental transfer and fetal metabolism of diazepam in early human pregnancy. Am J Obstet Gynecol 109: 1011–1061, 1971
Abramovich DR, Wade DP: Transplacental passage of steroids: The presence of corticosteroids in amniotic fluid. J Obstet Gynecol Br Commonw 76: 610–614, 1969
Anderson ABM, Gennser G, Jeremy JY, et al: Placental transfer and metabolism of betamethasone in human pregnancy. Obstet Gynecol 49: 471–474, 1977
Fouron JC: Dynamics of the placental transfer of digoxin in the dog. Biol Neonate 23: 116–122, 1973
Carrier G, Hume AS, Douglas BH, et al: Disposition of barbiturates in the maternal blood, fetal blood and amniotic fluid. Am J Obstet Gynecol 105: 1069–1071, 1969
Basso A, Fernandez A, Olthade O, et al: Passage of mannitol from mother to amniotic fluid to fetus. Obstet Gynecol 49: 628–631, 1977
Sack J, Fischer DA, Lam RW: Thyroid hormone metabolism in amniotic and allantoic fluids of the sheep. Pediatr Res 9: 837–841, 1975
Seeds AE: Current concepts of amniotic fluid dynamics. Am J Obstet Gynecol 138: 575–586, 1980
Duenhoeffer JH, Pritchard JA: Fetal respiration: Quantitative measurements of amniotic fluid inspired near term by human and rhesus fetuses. Am J Obstet Gynecol 125: 306–309, 1976
Shier RW, Sprague AD, Dilts PV: Placental transfer of meperidine HCI. Part II. Am J Obstet Gynecol 115: 556–559, 1973
Seeds AE: Basic concepts of maternal-fetal amniotic fluid exchange—their relevance to fetal therapeutics. Pediatr Clin North Am 28: 231–240, 1981
Shoeman DW, Kaufman RE, Azarnoff DL, et al: Placental transfer of diphenylhydantoin in the goat. Biochem Pharmacol 21: 1237–1244, 1972
Lien EJ, Kuwahara J, Koda RT: Diffusion of drugs into prostatic fluid and milk. Drug Intell Clin Pharm 8: 470–475, 1974
Catz CS, Giacoia GP: Drugs in breast milk. Pediatr Clin North Am 19: 151–166, 1972
Vorheer H: Drug excretion in breast milk. Postgrad Med 56: 97–104, 1974
Dickey RP: Drugs affecting lactation. Semin Perinatol 3: 279–286, 1979
Sousa PLR: Reestablishment of lactation with metoclopramide. J Trop Pediatr 21: 214–216, 1975
Briggs CG, Bodendorfer TW, Freeman RK, et al: Drugs in Pregnancy and Lactation. A Reference Guide to Fetal and Neonatal Risk. Baltimore, London, Williams & Wilkins, 1983
Barr WH: Principles of biopharmaceutics. Am J Pharm Educ 52: 958–981, 1968
Richens AL, Dunlop A: Serum-phenytoin levels in the management of epilepsy. Lancet 2: 247–248, 1975
Swintosky JV: Illustrations and pharmaceutical interpretations of first order drug elimination rate from the bloodstream. J Am Pharm Assoc Sci Ed 45: 395–400, 1956
Berkow R (ed): Merck Manual, ed 14. Rahway, Merck Sharp and Dohme Research Laboratories, 1982, p 2255
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Cupit, G.C., Rotmensch, H.H. (1985). Principles of Drug Therapy in Pregnancy. In: Gleicher, N. (eds) Principles of Medical Therapy in Pregnancy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2415-7_7
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DOI: https://doi.org/10.1007/978-1-4613-2415-7_7
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