Obstetric Ultrasound in the Management of Pregnancy Complicated by Maternal and Fetal Disease

  • Kara L. Mayden
  • Haim Elrad
  • Robert V. Giglia
  • Norbert Gleicher


The primary utilization of ultrasound occurred during World War II. Ultrasonic techniques were used in depth determinations and in the localization of submarines. After the Second World War, ultrasound was applied to human soft tissues. In the late 1950s and 1960s, advancements in equipment design, transducer quality, and photographic techniques provided investigators with an insight into the potential applications of sonography for medical diagnosis. The initial pieces of equipment were static compound imagers that provided a two-dimensional image. Over the years, the technique has improved, and the technology has advanced at a rapid rate.


Prenatal Diagnosis Chorionic Villus Epidermolysis Bullosa Intrauterine Growth Retardation Fetal Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Elkayam U, Kawaniski D, Reid CL, et al: Contrast echocardiography to reduce ionizing radiation associated with cardiac catheterization during pregnancy. Am J Cardiol 53: 213–214, 1983CrossRefGoogle Scholar
  2. 2.
    Sanders RC, James AE: Ultrasonography in Obstetrics and Gynecology, ed 2. New York, Appleton-Century-Crofts, 1982Google Scholar
  3. 3.
    Callen PW: Ultrasonography in Obstetrics and Gynecology. Philadelphia, WB Saunders, 1983Google Scholar
  4. 4.
    Hobbins JC, Winsberg F, Berkowitz RL: Ultrasonography in Obstetrics and Gynecology, ed 2. Baltimore, Williams & Wilkins, 1983Google Scholar
  5. 5.
    Kremkau FW: Biological effects and possible hazards. Clin Obstet Gynecol 10: 395–405, 1983Google Scholar
  6. 6.
    Ziskin MC: Basic physics of ultrasound, in Sanders RC, James AE (eds): Ultrasonography in Obstetrics and Gynecology. New York, Apple ton-Century-Crofts, 1977, pp 7–27Google Scholar
  7. 7.
    Sanders RC: Clinical Sonography: A Practical Guide. New York, Little, Brown, 1984, pp 3–25Google Scholar
  8. 8.
    Blackwell R: New developments in equipment. Clin Obstet Gynecol 10: 371–394, 1983Google Scholar
  9. 9.
    Ferrucci JT Jr: Body ultra sonography, part II. N Engl J Med 300: 538–542, 1979PubMedCrossRefGoogle Scholar
  10. 10.
    Wengert PA, Metzger PP, Ecker HA, et al: The use of ultra-sonography in the diagnosis of calculus gallbladder disease. Am Surg 45: 439–443, 1979PubMedGoogle Scholar
  11. 11.
    Feigenbaum H: Echocardiography. Philadelphia, Lea & Febiger, 1972, pp 1–23Google Scholar
  12. 12.
    Maurer G, Nanda N: Real-time two-dimensional echocardiography: Techniques and principles, in Linhart JW, Joyner CR (eds): Diagnostic Echocardiography. St Louis, CV Mosby, 1982Google Scholar
  13. 13.
    Lubchenco LO, Honsman C, Dressler M, et al: Intrauterine growth as estimated from liveborn birthweight data at 24 to 42 weeks of gestation. Pediatrics 32: 793–800, 1963PubMedGoogle Scholar
  14. 14.
    Stein ZA, Susser M: Intrauterine growth retardation. Semin Perinatol 8: 5–14, 1984PubMedGoogle Scholar
  15. 15.
    Campbell S, Dewhurst CJ: Diagnosis of the small-for-dates fetus by serial ultrasound cephalometry. Lancet 2: 1002–1006, 1971PubMedCrossRefGoogle Scholar
  16. 16.
    Campbell S: Ultrasound measurement of the fetal head to abdomen circumference ratio in assessment of growth retardation. Br J Obstet Gynaecol 84: 165–174, 1977PubMedCrossRefGoogle Scholar
  17. 17.
    Shepard MJ, Richards VA, Berkowitz RL, et al: An evaluation of two equations for predicting fetal weight by ultrasound. Am J Obstet Gynecol 142: 47–54, 1982PubMedGoogle Scholar
  18. 18.
    Hadlock FP, Deter RL, Harrist RB, et al: A date-independent predictor of intrauterine growth retardation: Femur length/ abdominal circumference ratio. Am J Roentgenol 141: 979–983, 1983Google Scholar
  19. 19.
    Hobbins JC: Use of ultrasound in complicated pregnancies. Clin Perinatol 7: 397–411, 1980PubMedGoogle Scholar
  20. 20.
    Elliot JP, Garite TJ, Freeman RK: Ultrasonic prediction of fetal macrosomia in diabetic patients. Obstet Gynecol 60: 159–162, 1982Google Scholar
  21. 21.
    Boyd ME, Usher RH, McLean FH: Fetal macrosomia: Prediction, risks, proposed management. Obstet Gynecol 61: 715–721, 1983PubMedGoogle Scholar
  22. 22.
    Houchang D, Modanlou HD, Komatsu G, et al: Large-for-gestational-age neonates. Anthropometric reasons for shoulder dystocia. Obstet Gynecol 60: 417–423, 1982Google Scholar
  23. 23.
    Reece EA, Hobbins JC: Ultrasound’s role in diabetic pregnancies. Contemp Ob/Gyn 23: 87–108, 1984Google Scholar
  24. 24.
    Liley AW: Liquor amnii analysis in the management of the pregnancy complicated by rhesus sensitization. Am J Obstet Gynecol 82: 1359–1370, 1961PubMedGoogle Scholar
  25. 25.
    Hobbins JC, Davis CD, Webster J: A new technique utilizing ultrasound to aid in intrauterine transfusion. J Clin Ultrasound 4: 135–137, 1976PubMedCrossRefGoogle Scholar
  26. 26.
    Berkowitz RL: Intrauterine transfusion, 1980, an update. Clin Perinatol 7: 283–297, 1980Google Scholar
  27. 27.
    Rodeck CH, Holman CA, Karnicki J, et al: Direct intravascular fetal blood transfusion by fetoscopy in severe rhesus isoimmunization. Lancet 1: 625–627, 1981PubMedCrossRefGoogle Scholar
  28. 28.
    Kleinman CS, Donnerstein RL, DeVore GR, et al: Fetal echocardiography for evaluation of in utero congestive heart failure—a technique for study of non-immune fetal hydrops. N Engl J Med 306: 568–575, 1982PubMedCrossRefGoogle Scholar
  29. 29.
    Brambati B, Simoni G: Diagnosis of fetal trisomy 21 in first trimester. Lancet 1: 586, 1983PubMedGoogle Scholar
  30. 30.
    Williamson R, Eskdale T, Coleman DV, et al: Direct gene analysis of chorionic villi: A possible technique for first-trimester antenatal diagnosis of haemoglobinopathies. Lancet 2: 1125–1127, 1981PubMedCrossRefGoogle Scholar
  31. 31.
    Kazy Z, Rozovsky IS, Bakharev VA: Chorion biopsy in early pregnancy: A method of early prenatal diagnosis for inherited disorders. Prenat Diagnos 2: 39–45, 1982CrossRefGoogle Scholar
  32. 32.
    Simoni G, Brambati B, Danesino C, et al: Efficient direct chromosome analyses and enzyme determinations from chorionic villi samples in the first trimester of pregnancy. Hum Genet 63: 349–357, 1983PubMedCrossRefGoogle Scholar
  33. 33.
    Department of Obstetrics and Gynaecology, Anshan: Fetal sex prediction of sex chromatin of chorionic villi cells during early pregnancy. Chin Med J [Engl] 1: 117–126, 1975Google Scholar
  34. 34.
    Horwell DH, Loeffler FE, Coleman DV: Assessment of a transcervical aspiration technique for chorionic villus biopsy in the first trimester of pregnancy. Br J Obstet Gynaecol 90: 196–198, 1983PubMedCrossRefGoogle Scholar
  35. 35.
    Ward RHT, Modell B, Petrou, et al: Method of sampling chorionic villi in first trimester of pregnancy under guidance of real-time ultrasound. Br Med J 286: 1542–1544, 1983CrossRefGoogle Scholar
  36. 36.
    Wapner R: Technical aspects of obtaining chorionic villi, Chorionic Villus Sampling Meeting, Chicago, March 22–23, 1983.Google Scholar
  37. 37.
    Hobbins JC: Determination of fetal sex in early pregnancy. N Engl J Med 309: 979–980, 1983PubMedCrossRefGoogle Scholar
  38. 38.
    Hobbins JC, Winsberg F, Berkowitz RL: Ultrasonography in Obstetrics and Gynecology, ed 2. Baltimore, Williams & Wilkins, 1983, pp 170–202Google Scholar
  39. 39.
    Jeanty P, Rodesch F, Romero R, et al: How to improve your amniocentesis technique. Am J Obstet Gynecol 146: 593–596, 1983PubMedGoogle Scholar
  40. 40.
    Chang H, Hobbins JC, Cividalli G, et al: In utero diagnosis of hemoglobinopathies in fetal red cells. N Engl J Med 290: 1067–1068, 1974PubMedCrossRefGoogle Scholar
  41. 41.
    Alter BP, Modell CB, Fairweather D, et al: Prenatal diagnosis of hemoglobinopathies. N Engl J Med 295: 1437–1443, 1976PubMedCrossRefGoogle Scholar
  42. 42.
    Mahoney MJ, Hobbins JC: Prenatal diagnosis of chondroectodermal dysplasia (Ellis-Van Creveld syndrome) with fetoscopy and ultrasound. N Engl J Med 297: 258–260, 1977PubMedCrossRefGoogle Scholar
  43. 43.
    Rodeck CH, Nicolaides KH: Ultrasound guided invasive procedures in obstetrics. Clin Obstet Gynecol 10: 515–539, 1983Google Scholar
  44. 44.
    Hobbins JC, Winsberg F, Berkowitz RL: Ultrasonography in Obstetrics and Gynecol, ed 2. Baltimore, Williams & Wilkins, 1983, pp 198–200Google Scholar
  45. 45.
    Hobbins JC, Mahoney MJ: In utero diagnosis of hemoglobinopathies. Technique for obtaining fetal blood. N Engl J Med 290: 1065–1067, 1974PubMedCrossRefGoogle Scholar
  46. 46.
    Rodeck CH, Campbell S: Umbilical cord insertion as a source of pure fetal blood for prenatal diagnosis. Lancet 1: 1244–1245, 1979PubMedCrossRefGoogle Scholar
  47. 47.
    Firshein SI, Hoyer LW, Lazarchick J, et al: Prenatal diagnosis of classic hemophilia. N Engl J Med 300: 937–941, 1979PubMedCrossRefGoogle Scholar
  48. 48.
    Rodeck CH, Campbell S: Sampling pure fetal blood by fetoscopy in second trimester of pregnancy. Br Med J 2: 728–730, 1978PubMedCrossRefGoogle Scholar
  49. 49.
    Kan YW, Golbus MS, Trecartin RF, et al: Prenatal diagnosis of R-thalassemia and sickle-cell anemia. Lancet 1: 269–271, 1977PubMedCrossRefGoogle Scholar
  50. 50.
    Alter BP, Friedman S, Hobbins JC, et al: Prenatal diagnosis of sickle cell anemia and alpha g-Philadelphia-a study of a fetus also at risk for HBS/β+ thalassemia. N Engl J Med 294: 1040–1041, 1976PubMedCrossRefGoogle Scholar
  51. 51.
    Rodeck CH, Eady RAJ, Gosden CM: Prenatal diagnosis of epidermolysis bullosa letalis. Lancet 1: 949–952, 1980PubMedCrossRefGoogle Scholar
  52. 52.
    Golbus MSA, Sagebiel RW, Filly RA, et al: Prenatal diagnosis of congenital bulbous ichthyosiform erythroderma (epidermolytic hyperkeratosis) by fetal skin biopsy. N Engl J Med 302: 93–95, 1980PubMedCrossRefGoogle Scholar
  53. 53.
    Rodeck CH, Patrick AD, Pembrey ME, et al: Fetal liver biopsy for prenatal diagnosis of ornithine carabanyl transferase deficiency. Lancet 1: 297–300, 1982CrossRefGoogle Scholar
  54. 54.
    Golbus MS, Harrison MR, Filly RA, et al: In utero treatment of urinary tract obstruction. Am J Obstet Gynecol 142: 383–388, 1982PubMedGoogle Scholar
  55. 55.
    Berkowitz RL, Glickman MG, Smith GJW, et al: Fetal urinary tract obstruction: What is the role of surgical intervention in utero? Am J Obstet Gynecol 144: 367–375, 1982PubMedGoogle Scholar
  56. 56.
    Birnholz JC, Frigoletto FD: Antenatal treatment of fetal hydrocephalus. N Engl J Med 304: 1021–1023, 1981PubMedCrossRefGoogle Scholar
  57. 57.
    Clewell WH, Johnson ML, Meier PR, et al: Placement of ventriculo-amniotic shunt for hydrocephalus in a fetus. N Engl J Med 305: 955, 1981PubMedGoogle Scholar
  58. 58.
    Consensus report: Fetal treatment 1982. N Eng J Med 307: 1651–1652, 1982CrossRefGoogle Scholar
  59. 59.
    Harrison MR, Ross NA, deLorimer AA: Correction of congenital diaphragmatic hernia in utero.III. Development of a successful surgical technique using abdominoplasty to avoid compromise of umbilical blood flow. J Pediatr Surg 16: 934–942, 1981PubMedCrossRefGoogle Scholar
  60. 60.
    Giglia RV, Mayden KL, Gleicher N: A Practical Guide to Real-time Office Sonography in Obstetrics and Gynecology. New York, Plenum Press, 1985Google Scholar
  61. 61.
    Grannum PAT, Tortora M, Mayden KL, et al: Obstetrical ultrasound, in Taylor KJW (ed): Atlas of Grey-Scale Ultrasonography, ed 2. New York, Churchill Livingston, 1985.Google Scholar
  62. 62.
    Chervenak FA, Berkowitz RL, Romero R, et al: The diagnosis of fetal hydrocephalus. Am J Obstet Gynecol 147: 703–716, 1983PubMedGoogle Scholar
  63. 63.
    Nicolaides KH, Rodeck CH: Future muscle wasting: Greatest hope lies in gene therapy. Gen Practitioner, Dec 3, 1982, p 44Google Scholar
  64. 64.
    DeVore GR, Venus I, Hobbins JC, et al: Fetoscopy, in Rocker I, Lawrence KM (eds): Fetoscopy. New York, Elsevier/ North-Holland, 1981, pp 51–64Google Scholar

Copyright information

© Plenum Press Publishing Corporation 1985

Authors and Affiliations

  • Kara L. Mayden
  • Haim Elrad
  • Robert V. Giglia
  • Norbert Gleicher

There are no affiliations available

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