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The HLA Complex

  • Janardan P. Pandey

Abstract

The major histocompatibility complex (MHC) in man, termed HLA, is a highly polymorphic multigene system located on the short arm of chromosome 6 (Fig. 143–1). Most phenomena associated with the MHC are immunologic in nature, but it has also been associated with some that cannot readily be claimed by immunology (e.g., 21-hydroxylase deficiency). At least three classes of molecules are controlled by the MHC. Class I molecules, HLA-A, -B, and -C, are responsible for graft rejection and regulate the killing of virus-infected cells. Class II molecules, encoded by at least four loci, D, DR, DC, and SB, control communication between lymphoid cells. The HLA-A,B,C determinants are present on most nucleated tissues, whereas D-related antigens are found mainly on B lymphocytes and macrophages. Finally, class III molecules are components of the serum complement system, C2, C4A, C4B, and Bf; these proteins participate in cell lysis. The MHC loci are very closely linked (crossing over less than 1%).

Keywords

Systemic Lupus Erythematosus Major Histocompatibility Complex Congenital Adrenal Hyperplasia Major Histocompatibility Complex Region Major Histocompatibility Complex Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

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  • Janardan P. Pandey

There are no affiliations available

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