Relationship between Mutagenesis and Carcinogenesis

  • Claes Ramel
Part of the Environmental Science Research book series (ESRH, volume 31)

Summary

The sequence of events in cancer induction is usually thought to include at least three steps — initiation, promotion and progression. Several lines of evidence speak in favor of a mutational origin of cancer, particularly at the initiation level. This evidence is mostly indirect, but recent analyses of oncogenes have given the theory more direct support. These investigations have indicated that base substitutions as well as chromosomal rearrangements are involved. Other genetic mechanisms of cancer initiation have also been suggested, such as hypomethylation of DNA bases and transposition of DNA segments. However the lack of response both of prokaryotic and eukaryotic transposable elements to carcinogenic agents makes it doubtful whether transpositions are involved in chemically induced cancer. Although experimental data clearly indicate that alterations of DNA are involved in cancer induction, there are also experimental observations on nuclear transplantations, on transmission of induced cancer properties to the offspring, and on the frequency of neoplastic transformations, which are not readily explained by a mutational origin of cancer. Although this circumstance calls for some cautiousness in excluding a nongenetic origin of cancer in some cases, there are nevertheless strong reasons to believe that some kind of somatic mutation events constitute the predominant mechanism for cancer initiation. At the practical screening level the empirical correlation between results from animal cancer tests and short term mutagenicity assays has given a firm foundation for the use of mutagenicity screening for prediction of carcinogenicity.

Keywords

Lymphoma Glutathione Catalase Myeloma Guanine 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Claes Ramel
    • 1
  1. 1.Wallenberg LaboratoryUniversity of StockholmStockholmSweden

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