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Isolation and Identification of Direct-Acting Mutagens in Diesel Exhaust

  • X. B. Xu
  • Z. L. Jin
  • E. T. Wei
  • J. P. Nachtman
  • S. M. Rappaport
  • A. L. Burlingame
Part of the Environmental Science Research book series (ESRH, volume 31)

Abstract

The mutagenicity obtained in the absence of activation by mammalian oxidative enzymes in the Ames Salmonella assay of particulates from air or from engine exhaust indicated that these particulates contain chemicals of unrecognized toxic potentials other than unsubstituted polynuclear aromatic hydrocarbons (PAH). Bioassay (strain TA 98, without S-9) directed fractionation and characterization studies of a combined diesel exhaust sample of 225 g organic extracts had been carried out over the last two years in our laboratories for the purpose of identifying those so called “direct-acting” mutagens.

Keywords

Diesel Exhaust Sister Chromatid Exchange Xeroderma Pigmentosum Engine Exhaust Polynuclear Aromatic Hydrocarbon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • X. B. Xu
    • 1
  • Z. L. Jin
    • 1
  • E. T. Wei
    • 2
  • J. P. Nachtman
    • 2
  • S. M. Rappaport
    • 2
  • A. L. Burlingame
    • 3
  1. 1.Institute of Environmental ChemistryAcademia SinicaBeijingChina
  2. 2.School of Public HealthUniversity of CaliforniaBerkeleyUSA
  3. 3.School of PharmacyUniversity of CaliforniaSan FranciscoUSA

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