Abstract
This paper presents the results of testing gossypol acetate for the possible induction of sister chromatid exchanges (SCEs) in mouse spermatogonial cells in vivo following a single intraperitoneal injection of BudR adsorbed on charcoal. Our purpose was to elucidate the mutagenecity of gossypol. Animals were randomly divided into five groups: the lower, medium, and higher dosage groups (5, 20, and 50 times as high as gossypol clinical dosage, respectively), the negative control group and the positive control group (Mitomycin C 0.5 mg/kg b.w. ). The results are:
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1.
Comparing the SCE frequencies of the lower dosage group (1.42 ± 0.006/cell) and the medium dosage group (1.43 ± 0.06/cell) with the negative control group (1.43 ± 0.07/cell), the differences were not statiscally significant (p > 0.05).
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2.
The difference between the higher dosage group (1.84 ± 0.07/cell) and the negative control group was highly significant (p < 0.001).
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© 1984 Plenum Press, New York
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Wang, R.L. et al. (1984). Induction of Sister Chromatid Exchanges with Gossypol Acetate in Mouse Spermatogonial Cells In Vivo. In: Chu, E.H.Y., Generoso, W.M. (eds) Mutation, Cancer, and Malformation. Environmental Science Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2399-0_46
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DOI: https://doi.org/10.1007/978-1-4613-2399-0_46
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4613-2399-0
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