Abstract
At the present time methotrexate (MTX) is probably the only cytotoxic drug for which therapeutic drug monitoring is important. Radioimmunoassay (RIA), HPLC and enzyme inhibition assays have all been used for this purpose [cf. arts in this vol. by S.H. Curry,#E-3, and J.W. Paxton, #NC(D)-5]. Comparative studies have shown that immunoassay techniques tend to slightly overestimate plasma MTX concentrations especially at late time points [l, 2], although in another study [3] it was concluded that for monitoring purposes any of the techniques was suitable.
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© 1984 Plenum Press, New York
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Aherne, G.W., Lawson, D.J., Quinton, M., Marks, V. (1984). Combined RIA/HPLC of Methotrexate and its Metabolites. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_33
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_33
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