Abstract
Drugs labelled with stable isotopes may be used in three different ways for pharmacokinetic studies.-
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(1)
Stable isotope dilution: ‘analytical’ internal standard.
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(2)
Administration of labelled drug alone.
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(3)
Co-administration of unlabelled and labelled forms of a drug — ‘biological’ internal standard.
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References
Millard, B.J. (1978) Quantitative Mass Spectrometry, Heyden, London, 160 pp.
Draffan, G.H. (1978) in Stable Isotopes, Applications(Baillie, T.A., ed.), Macmillan, London, pp. 27 – 42.
Baba, S., Kato, S., Morishita, S. & Sone, H. (1978) J. Med. Chem. 21, 525 – 529.
Eichelbaum, M., von Unruh, G.E. & Somogyi, A. (1982) Clin. Pharmacokin. 7, 490 – 507
Hege, H.G. & Weymann, J. (1982) in Stable Isotopes [Proc. 4th Int. Conf., Juelich, 1981] (Schmidt, H.-L., Foerstel, H. & Heinzinger, K., eds.), G. Fischer, Stuttgart, pp. 679 – 684.
von Unruh, G.E., Jancik, B.C. & Hoffmann, F. (1980) Biomed. Mass Spectrom. 7, 164 – 167.
Wolf, D., Cohen, H., Meshorer, A., Wasserman, I. & Samuel, D. (1979) in Stable Isotopes [Proc. 3rd Int. Conf.](Klein, E.R. & Klein, P.D., eds.), Academic Press, New York, pp. 353 - 360.
Horning, M.G., Haegele, K.D. & Brendel, K. (1978) in Stable Isotopes, Applications in Pharmacology, Toxicology & Clinical Research(Baillie, T.A., ed.), Macmillan, London, pp. 55 – 64.
Gugler, R. & von Unruh, G.E. (1980) Clin. Pharmacokin. 5, 67 – 83.
Hoffmann, F., von Unruh, G.E. & Jancik, B.C. (1981) Br. J. Clin. Pharmacol.13, 383 – 385.
d–A. Heck, H., Buttril, S.E., Flynn, N.W., Dyer, R.L., Anbar, M., Cairns, T., Dighe, S. & Cabana, B.E. (1979) J- Pharmacokin. Biopharm. 7, 233 – 248.
Eichelbaum, M., Somogyi, A., von Unruh, G.E. & Dengler, H.J. (1981) Eur. J. Clin. Pharmacol. 19, 133–137 (see also 127–131).
Eichelbaum, M., Kothe, K.W., Hoffmann, F. & von Unruh, G.E. (1982) Eur. J. Clin. Pharmacol. 23, 241 – 244.
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© 1984 Plenum Press,New York
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von Unruh, G.E., Eichelbaum, M., Dengler, H.J. (1984). Stable Isotopes in Pharmacokinetic Studies. In: Reid, E., Wilson, I.D. (eds) Drug Determination in Therapeutic and Forensic Contexts. Methodological Surveys in Biochemistry and Analysis, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2397-6_3
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DOI: https://doi.org/10.1007/978-1-4613-2397-6_3
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