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HPLC-Electrochemical Determination of CIS-Platinum Anti-Cancer Drugs

  • I. S. Krull
  • X-D. Ding
  • C. Selavka
  • F. Hochberg
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 14)

Abstract

Liquid chromatography-electrochemical detection (LCEC) has been applied to the trace determination of drugs [chemical names below] termed cis-Pt, CBDCA and CHIP. cis-Pt, the parent compound, can be determined by either oxidative or reductive LCEC, with different detection limits. Both CBDCA and CHIP can be determined by direct LCEC, but the detection limits for CBDCA are too high for clinical or stability studies. With a new derivatization method for CBDCA and related Pt compounds CBDCA is quantitatively convertible to cis-Pt, determination of which by reductive LCEC allows CDDP assay in plasma at the 0.1 μ/ml level (100 ppb.)

Keywords

Glassy Carbon Glassy Carbon Electrode Massachusetts General Hospital Trace Determination Bioanalytical System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Prestakyo, A.W., Crooke, S.T. & Carter, S.K., eds. (1980) Cis- platin: Current Status and New Developments, Acad. Press, New York.Google Scholar
  2. 2.
    Krull, I.S. (1984) in Liquid Chromatography in Environmental Analysis (Lawrence, J.F., ed.), Humana Press, Clifton, NJ, Chapter 5.Google Scholar
  3. 3.
    Schwedt, G. (1981) Chromatographic Methods in Inorganic Analysis: Separation Methods, A. Hüthig, Heidelberg, 226 pp.Google Scholar
  4. 4.
    Vickrey, T.M., ed. (1983) Liquid Chromatography Detectors(Vol. 23, Chromatographic Science Series), Dekker, New York, 434 pp.Google Scholar
  5. 5.
    Riley, C.M., Sternson, L.A. & Repta, A.J. (1982) Anal. Biochem. 124, 167 – 179.CrossRefGoogle Scholar
  6. 6.
    Bannister, S.T., Sternson, L.A. & Repta, A.J. (1983) J. Chromatog. 273, 301 – 318.CrossRefGoogle Scholar
  7. 7.
    Krull, I.S., Ding, X-D., Braverman, S., Selavka, C., Hochberg, F. & Sternson, L.A. (1983) J. Chromatog. Sci. 21, 166 – 173Google Scholar
  8. 8.
    Ding, X-D. & Krull, I.S. (1983) J. Liq. Chromatog. 6, 2173– 2194.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • I. S. Krull
    • 1
  • X-D. Ding
    • 1
  • C. Selavka
    • 1
  • F. Hochberg
    • 2
  1. 1.Institute of Chemical AnalysisNortheastern UniversityBostonUSA
  2. 2.Neurology-Oncology DivisionMassachusetts General HospitalBostonUSA

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