Calcification of Cardiac Valve Bioprostheses
Glutaraldehyde-preserved stent-mounted porcine aortic valve bioprostheses are widely used in the surgical management of valvular heart disease [3,13,16,17]. Since 1971, several hundred thousand have been implanted in patients undergoing cardiac valve replacement. In most cases, bioprostheses offer the distinct advantages of freedom from chronic anticoagulation and favorable hemodynamic performance. However, calcification of bioprostheses is frequent after long-term function [16,17]. Mineral deposits often lead to clinically significant valvar dysfunction, which usually necessitates reoperation, but is occasionally fatal.
KeywordsPhosphorus Magnesium Aldehyde Pyridinium Warfarin
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