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Calcium in Biological Systems pp 411–421Cite as

Cellular and Subcellular Approaches to the Mechanism of Action of Calcium Antagonists

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Abstract

The concept of Ca2+ antagonism has been developed on the basis of two different and parallel experimental approaches, one being mainly supported by studies on smooth muscle [14,18], the other on cardiac muscle [6]In previous cardiac muscle studies, not all of the effects of Ca2+ antagonists could be attributed to inhibition of Ca2+ entry, as some effects were still observed after Ca2+ withdrawal [7]The present chapter will summarize the development of studies in my laboratory which deal with the mechanisms of action of Ca2+ antagonists in smooth muscle.

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Author information

Authors and Affiliations

  1. Laboratory of Pharmacodynamics and Pharmacology, Catholic University of Louvain, Brussels, B-1200, Belgium

    T. Godfraind

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  1. T. Godfraind
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Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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Godfraind, T. (1985). Cellular and Subcellular Approaches to the Mechanism of Action of Calcium Antagonists. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_45

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

  • eBook Packages: Springer Book Archive

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