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Mechanisms of Pharmacologically Altering Calmodulin Activity

  • Walter C. Prozialeck
  • Benjamin Weiss

Abstract

Considerable evidence has now accumulated indicating that calmodulin is the principal mediator of the effects of Ca2+ in most eukaryotic cells [for reviews see 3,8,24,25]. Since calmodulin plays such a fundamental role in cell biology, agents that inhibit its activity should produce important pharmacological effects. An understanding of the mechanisms by which drugs alter calmodulin activity may suggest new approaches for modifying various physiological or pathological processes. Furthermore, the development of selective calmodulin antagonists may provide a useful means for further studying the biological roles of calmodulin.

Keywords

Phosphodiesterase Activity Cyclic Nucleotide Phosphodiesterase Calmodulin Antagonist Calmodulin Inhibitor Calmodulin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Walter C. Prozialeck
    • 1
  • Benjamin Weiss
    • 2
  1. 1.Department of Physiology and PharmacologyPhiladelphia College of Osteopathic MedicinePhiladelphiaUSA
  2. 2.Department of PharmacologyMedical College of PennsylvaniaPhiladelphiaUSA

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