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Psychiatry pp 99-107 | Cite as

Genetic Factors in Alcoholism: A Theoretical Model

  • Marc A. Schuckit

Abstract

Research into alcoholic phenomena has made great strides in recent years (1), Much of our understanding of tolerance, withdrawal from brain depressants, and postwithdrawal syndromes has arisen from careful observation of alcoholics, making comparisons with the physiological status of normal controls.

Keywords

Family History Positive Family History Negative Major Psychiatric Disorder Acute Reaction Acute Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Institute of Medicine: Alcoholism and Related Problems: Opportunities for Research. National Academy of Sciences, Washington, D.C. (1980).Google Scholar
  2. 2.
    Schuckit MA: Alcoholism and genetics: Possible Biological Mediators. Biological Psychiatry 15: 437–447, (1980).Google Scholar
  3. 3.
    Goodwin DW, Schulsinger F, Moller N, et al: Drinking problems in adopted and nonadopted sons of alcoholics. Arch Gen Psychiat 31: 164–169, (1974).PubMedGoogle Scholar
  4. 4.
    Bohman M, Sigvardsson S, & Cloninger CR: Maternal inheritance of alcohol abuse. Cross-fostering analysis of adopted women. Arch Gen Psychiat 38: 965–969, (1981).PubMedGoogle Scholar
  5. 5.
    Schuckit MA: Biological markers: Metabolism and acute reactions to alcohol in sons of alcoholics. Proceedings of the “5th Biennial International Symposium on Alcoholism”, Cardiff Wales, June 9–13, 1980. Pharmacology, Biochemistry and Behavior, 13: 9–16, (1980).Google Scholar
  6. 6.
    Saunders GR & Schuckit MA: MMPI scores in young men with alcoholic relatives and controls. Journal of Nervous and Mental Disorder 169: 456–458, (1981).CrossRefGoogle Scholar
  7. 7.
    Schuckit MA and Rayses V: Differences in acetaldehyde levels in relatives of alcoholics and controls. Science 203: 54–55, (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    Schuckit MA: Subjective response to alcohol in sons of alcoholics and controls. Arch Gen Psychiat. In Press.Google Scholar
  9. 9.
    Haglund RMJ and Schuckit MA: The epidemiology of alcoholism. In: Estes N and Heinemann E (eds); Alcoholism: Development, Consequences and Interventions 2nd Edition, CV Mosby Co. St. Louis, MO., (1982).Google Scholar
  10. 10.
    Jones BM: Alcohol and women: Intoxication levels and memory impairment’s related to the menstrual cycle. Ale Technical Reports 4: 4–10, (1975).Google Scholar
  11. 11.
    Cahalan D: Problem Drinkers. Jossey-Bass, San Francisco, (1970).Google Scholar
  12. 12.
    Scuckit MA: Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment, 1st Edition. Plenum Publishing Corp., New York, (1979).Google Scholar
  13. 13.
    Schuckit MA: Self-ratinzg alcohol intoxication by young men with and without family histories of alcoholism. Journal of Studies on Alcohol 41: 242–249, (1980).Google Scholar
  14. 14.
    Schuckit MA, Parker DC and Rossman LR: Prglactin responses to ethanol in men at elevated risk for alcoholism and controls. Biological Psychiatry, in press.Google Scholar
  15. 15.
    Schuckit MA: Differential effects of ethanol on plasma Cortisol in relatives of alcoholics and controls: Preliminary results. Journal of Clinical Psychiatry, in press.Google Scholar
  16. 16.
    Cloninger CR and Reich T: Genetic heterogeneity in alcoholism and sociopathy. In: Proceedings of Association for Research in Nervous and Mental Disease, Genetics of Neurological and Psychiatric Disorders, Kety SS (ed), Raven Press, New York, (1981).Google Scholar
  17. 17.
    Schuckit MA and von Wartburg JP: Hypothesis: Developing a model of causation for alcoholism. Journal of Studies on Alcohol, in press.Google Scholar
  18. 18.
    von Wartburg JP: Variability of human alcohol metabolism. Presented at the Symposium on “Endocrinological Aspects” “of Ethanol Tolerance and Dependence”,Washington University, St. Louis, Missouri. September, 1982.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.Alcohol Treatment Program, Veterans AdministrationUniversity of California San Diego Medical SchoolSan DiegoUSA

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