Membranes, Lipids and the Lithium-Responsive Psychoses
The work described in the present report derives from the working hypothesis that “the Li+-responsive psychoses, like many other neurological disorders (e.g., see ref.1), are the manifestation of abnormalities in membrane composition and organization”. Furthermore, it is assumed that these abnormalities are trait factors which are expressed not only in the brain but in other tissues as well. With this hypothesis in mind we have focused our investigation on three issues:(a) Li+ transport, (b) membrane lipid composition and (c) phospholipid methylation.
KeywordsLithium Attenuation Schizophrenia Serine Methionine
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