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Membranes, Lipids and the Lithium-Responsive Psychoses

  • Robert J. Hitzemann
  • David L. Garver
  • Jack Hirschowitz

Abstract

The work described in the present report derives from the working hypothesis that “the Li+-responsive psychoses, like many other neurological disorders (e.g., see ref.1), are the manifestation of abnormalities in membrane composition and organization”. Furthermore, it is assumed that these abnormalities are trait factors which are expressed not only in the brain but in other tissues as well. With this hypothesis in mind we have focused our investigation on three issues:(a) Li+ transport, (b) membrane lipid composition and (c) phospholipid methylation.

Keywords

Membrane Composition Methylation Activity Membrane Lipid Composition Erythrocyte Ghost Ghost Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Robert J. Hitzemann
    • 1
  • David L. Garver
    • 1
  • Jack Hirschowitz
    • 1
  1. 1.University of Cincinnati College of MedicineCincinnatiUSA

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