Membranes, Lipids and the Lithium-Responsive Psychoses

  • Robert J. Hitzemann
  • David L. Garver
  • Jack Hirschowitz


The work described in the present report derives from the working hypothesis that “the Li+-responsive psychoses, like many other neurological disorders (e.g., see ref.1), are the manifestation of abnormalities in membrane composition and organization”. Furthermore, it is assumed that these abnormalities are trait factors which are expressed not only in the brain but in other tissues as well. With this hypothesis in mind we have focused our investigation on three issues:(a) Li+ transport, (b) membrane lipid composition and (c) phospholipid methylation.


Membrane Composition Methylation Activity Membrane Lipid Composition Erythrocyte Ghost Ghost Membrane 
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  1. 1.
    Butterfield, D.A. and Markesbeny, W.R., Specificity of biophysical and biochemical alterations in erythrocyte membranes with neurological disorders. J. Neurological Sci. 97:261–271 (1980).CrossRefGoogle Scholar
  2. 2.
    Ehrlich, B.E. and Diamond, J.M., Lithium membranes and manic-depressive illness. J. Membr. Biol. 52:187–200 (1980).PubMedCrossRefGoogle Scholar
  3. 3.
    Greil, W., Eisenreid, F., Becher, B.F. and Duhm, J., Inter-individual differences in the Na+-dependent Li+ countertrans- port system and in the Li+ distribution ratio across the red cell membrane among Li+ treated patients. Psychopharmacol. 53:19–26 (1977).CrossRefGoogle Scholar
  4. 4.
    Meltzer, H.L., Kassir, S., Dunner, D.L. and Fieve, R.R., Repression of a lithium pump as a consequence of lithium ingestion by manic-depressive subjects. Psychopharmacologia. 54:113–118 (1977).CrossRefGoogle Scholar
  5. 5.
    Hitzemann, R.J. and Garver, D.L., Membrane abnormalities in lithium responsive illnesses. In:Hanin, I., and Usdin, E. (eds.) Biological Markers in Psychiatry and Neurology. New York:Pergamon Press, pp. 177–182 (1982).Google Scholar
  6. 6.
    Blusztajn, J.K., Zeisel, S.H., Wurtman, R.J., Synthesis of lechithin (phospatidylcholine) from phosphatidylethanolamine in bovine brain. Brain Res. 179:319–327 (1979).PubMedCrossRefGoogle Scholar
  7. 7.
    Blusztajn, J.K. Wurtman, R.J., The choline cycle:evidence of synthesis of choline from serine and methionine in rat brain. Neurosci. Abst. 8:143. 9 (1982).Google Scholar
  8. 8.
    Edelstein, P., Schultz, J.R., Hirschowitz, J., Kanter, D.R., and Garver, D.L., Physostigmine and lithium response in the schizophrenias. Am. J. Psychiat. 138:8 1078–1081.Google Scholar
  9. 9.
    Jope, R.S., Effects of lithium treatments in vitro and in vivo on acetylcholine metabolism in rat brain. J. Neurochem. 33:487–495 (1979).PubMedCrossRefGoogle Scholar
  10. 10.
    Hirschowitz, J., Casper, R., Garver, D., and Chang, S., Lithium response in good-prognosis schizophrenia. Am. J. Psychiat. 137:916–920 (1980).PubMedGoogle Scholar
  11. 11.
    Pandey, G.N., Baker, J., Chang, S. and Davis, J., Predictions of in vivo red cell/plasma Li+ ratios by in vitro methods. Clin. Pharm. Therap. 24:343–349 (1978).PubMedGoogle Scholar
  12. 12.
    Pandey, G.N., Sarkardi, B., Haas, M., Gunn, R.B., Davis, J.M. and Tosteson, D.C., Lithium transport pathways in human red blood cells. J. Gen. Physiol. 72:233–247 (1978).PubMedCrossRefGoogle Scholar
  13. 13.
    Crews. F.T., Hirata, F., and Axelrod, J., Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J. Neurochem. 34:1491–1498 (1980).PubMedCrossRefGoogle Scholar
  14. 14.
    Hirata, F., and Axelrod, J., Phospholipid methylation and biological signal transmission. Science, 209:1082–1090 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Robert J. Hitzemann
    • 1
  • David L. Garver
    • 1
  • Jack Hirschowitz
    • 1
  1. 1.University of Cincinnati College of MedicineCincinnatiUSA

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