Skip to main content

Antidepressive Efficacy of Pirlindole in Man

  • Chapter
Psychiatry the State of the Art

Abstract

Pirlindole is a selective MAO type A inhibitor and its clinical efficacy as an antidepressive drug has been established in several studies (this volume). The present investigation was undertaken in order to examine the following questions. First, is there any difference in the improvement of the single subscores of the depression rating scales during a period of treatment of five weeks. Second, are there any side effects of the drug when abruptly changing medication from pirlindole to a common tricyclic or tetracyclic antidepressant. Furthermore, we were interested in comparing a subgroup of responders and nonresponders with respect to possible differences in endocrine and biochemical parameters before and after three weeks of treatment with pirlindole.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.L. Spitzer, J. Endicott, E. Robins, Research Diagnostic Criteria (RDC) for a selected group of functional disorders, 3rd edition, New York State Psychiatry Institute (1978).

    Google Scholar 

  2. M. Hamilton, A rating scale for depression, J. Neurol. Neurosurg. Psychiat. 25: 56 (1960).

    Article  Google Scholar 

  3. J.E. Overall, D.R. Gorham, The Brief Psychiatric Rating Scale. Psychol Rep. 10: 799 (1962).

    Google Scholar 

  4. W.W.K. Zung, A self-rating depression scale, Arch. Gen. Psychiat. 12: 63 (1965).

    PubMed  CAS  Google Scholar 

  5. B.J. Carrol, Implications of biological research for the diagnosis of depression, in “New Advances in the Diagnosis and Treatment of Depressive Illness”, J. Mendelwicz, ed., Elsevier, Amsterdam (1981).

    Google Scholar 

  6. W. Guy (ed.), National Institute of Mental Health, 029 DOTES. Dosage Record and Treatment Emergent Symptom Scale, in “ECDEU Assessment Manual for Psychopharmacology”, rev. ed., Rockville, Maryland (1976).

    Google Scholar 

  7. Arbeitsgemeinschaft für Methodik and Dokumentation in der Psychiatrie AMDP. Das AMDP-System. Manual zur Dokumentation psychiatrischer Befunde. 3. Aufl., Springer Verlag, Berlin, Heidelberg, New York (1979).

    Google Scholar 

  8. D.V. Zerssen, D.-M. Koeller, E.R. Rey, Die Befindlichkeits-Skala (B-S)- ein einfachtes Instrument zur Objektivierung von Befindlichkeits-Störungen, insbesondere im Rahmen von Längsschnitt-Untersuchungen, Arzneimittel. - Forschung 20: 915 (1970).

    Google Scholar 

  9. M. Schmauβ, P. Meyr, Kombinationstherapie tri- und tetra- zyklischer Antidepressiva mit MAO-Hemmern, Psycho. 9: 373 (1983).

    Google Scholar 

  10. J. Anath, D. Lucins, A review of combined tricyclic and MAOI therapy, Compr. Psychiatry 18: 121 (1977)

    Google Scholar 

  11. M. Schuckit, E. Robins, J. Feighner, Tricyclic antidepressant and MAO-inhibitors, Arch. Gen. Psychiat. 24: 509 (1971).

    PubMed  CAS  Google Scholar 

  12. W.A. Brown, R. Johnston, D. Mayfield, The 24-hour dexa- methasone suppression test in a clinical setting: Relationship to diagnosis, symptoms and response to treatment, Am. J. Psychiat. 136: 543 (1979).

    PubMed  CAS  Google Scholar 

  13. L.Demisch, K. Syha, K. Demisch, G. Buchholz, R. Kirsten and K. Nelson, Biochemical effects of pirlindole in man, this volume

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Buchholz, G., Demisch, K., Demisch, L., Bochnik, H.J. (1985). Antidepressive Efficacy of Pirlindole in Man. In: Pichot, P., Berner, P., Wolf, R., Thau, K. (eds) Psychiatry the State of the Art. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2363-1_51

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2363-1_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9446-7

  • Online ISBN: 978-1-4613-2363-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics