Abstract
Pirlindole (PIR), a tetracyclic indole derivative, is a new antidepressant drug (AD) which inactivates monoamine oxidase and inhibits the uptake of noradrenaline (NA) (Mashkovsky et al., 1975; Martorana and Nitz, 1983). According to these properties PIR shows a pharmacological profile similar to that characteristic of typical AD, although some differences have been found.
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References
Braestrup, C. and Squires, R.F., 1978, Pharmacological characterization of benzodiazepine receptors in the brain, Eur.J.Pharmacol., 48: 263.
Briley, N. and Langer, S.Z., 1978, Two binding sites for 3H-spiroperidol on rat striatal membranes, Eur.J. Pharmacol., 50:283.
Corne, S.J., Pickering, R.W. and Warner, B.T., 1963, Method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine, Br.J.Pharmacol., 20: 106.
Earley, C.J. and Leonard, B.E., 1978, Isolation and assay of noradrenaline, dopamine, 5-hydroxytryptamine and several metabolites from brain tissue using disposable bio-rad columnes packed with Sephadex G-10, J. Pharmacol.Methods, 1:67.
Fiedler, V.B., Buchheim, S., Nitz, R.-E. and Scholtholt, J., 1983, Haemodynamic effects of pirlindole, a new tetracyclic antidepressant agent, Arzneim.-Forsch., 33: 244.
Hyttel, J., 1981, Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro, Life Sci., 28: 563.
Ma j, J., Palider, W. and Baran, L., 1976, The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor, J.Neural Transm., 38: 131.
Martorana, P.A. and Nitz, R.-E., 1979, The new antidepressant pirlindole. A comparison with imipramine and tranylcypromine, Arzneim.-Forsch., 29: 946.
Mashkovsky, M.D. and Andreeva, N.I., 1981, Comparative pharmacological study of some new antidepressant, Farmacol.Toxicol., 44: 698.
Mashkovsky, M.D., Gorkhin, V.Z., Andreeva, N.I., Verevkina, V.I., Sinyukhin, V.N., Asnina, V.A. and Zhuraleva, G.V., 1975, Investigation into the mechanism of action produced by a new antidepressant pyrazidol, Farmacol.Toxicol., 38: 531.
Minneman, K.P., Pittman, R.N. and Molinoff, P.B., 1981, β-adrenergic receptor subtypes: properties, distribution, and regulation, Ann.Rev.Neurosci., 4:419.
Porsolt, R.D., Bertin, A. and Jalfre, M., 1977, Behavioural despair in mice: a primary screening test for antidepressants, Arch.Int.Pharmacodyn.Ther., 229: 327.
Sulpizio, A., Fowler, P.J. and Macko, E., 1978, Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition, Life Sci., 22: 1439.
Vetulani, J., 1983, Changes in responsiveness of central aminergic structures after chronic ECS, in: “ECT: Basic Mechanisms”, B. Lerer, E.D. Weiner, R.H. Belmaker, eds., John Libbey et Co., London, Paris, p. 33.
Vetulani, J., Reichenberg, K. and Wiszniowska, G., 1974, The ineffectiveness of desipramine pretreatment on behavioral effects of 6-hydroxydopamine in nialamide -pretreated rats, Psychopharmacologia (Berl.), 38: 173.
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© 1985 Plenum Press, New York
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Maj, J., Michaluk, J., Rawłów, A., Rogóz, Z., Skuza, G. (1985). About the Central Effect of Pirlindole, A New Antidepressant. In: Pichot, P., Berner, P., Wolf, R., Thau, K. (eds) Psychiatry the State of the Art. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2363-1_32
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DOI: https://doi.org/10.1007/978-1-4613-2363-1_32
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