On the Value of CNS, ANS and Behavioral Measures in Early Clinical Psychopharmacology

  • Bernd Saletu
  • Josef Grünberger
  • Leopold Linzmayer
  • Werner Sieghart

Abstract

The ever increasing number of newly developed potentially psychoactive compounds since 1952 resulted in a need for screening methods in early clinical pharmacology. The quantitative analysis of the human scalp-recorded EEG in combination with certain statistical procedures (called “quantitative pharmaco-EEG”) along with psychometric methods has been proven to mediate valuable objective and quantitative information about the effect of psychotropic drugs on their target organ— the human brain — and on human behavior (Fink, 1969, Saletu, 1976; Grünberger and Saletu, 1980). It seems possible to predict 1) if; 2) how; 3) in which dosage; 4) at which time a new compound will act, which will be shown by an example of a recently performed pharmaco-EEG and psychometric study with temazepam—a relatively new benzodiazepine with the advantage of a short half life and lack of active metabolites.

Keywords

Placebo Half Life Diazepam Haloperidol Imipramine 

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References

  1. Fink, M., 1969, EEG and human psychopharmacology. A.Rev.Pharmac. 9: 241.CrossRefGoogle Scholar
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  4. Saletu, B., Grünberger, J., Anderer, P., 1983, Abendliches Fernsehen und Schlaf-polysomnographische, psychometrische und psycho-pharmakologische Untersuchungen bei Schlafgestörten, Med.Welt., 34: 829.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Bernd Saletu
    • 1
  • Josef Grünberger
    • 1
  • Leopold Linzmayer
    • 1
  • Werner Sieghart
    • 1
  1. 1.Section of PharmacopsychiatryPsychiatric University ClinicViennaAustria

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