Fibronectin and Reticuloendothelial Clearance of Blood-Borne Particles Clinical Studies in Septic Shock

  • Thomas M. Saba

Abstract

Sepsis in patients following blunt trauma, burn, and major surgery is etiologic in the high incidence of organ dysfunction as well as morbidity and mortality (Fulton and Jones, 1975; Saba et al., 1980; Saba and Jaffe, 1980). Indeed, even with modern surgical techniques, advances in antimicrobial therapy, and sophisticated patient monitoring, the death rate in the severely injured patient is very high due to the delayed development of organ failure with the onset of severe sepsis (Scovill et al., 1978; Saba and Jaffe, 1980; Powers and Saba, 1981). Recent data suggest that this may be related to organ microembolization and diffuse altered vascular permeability coupled with failure of reticuloendothelial host defense mechanisms.

Keywords

Permeability Depression Ischemia Heparin Pseudomonas 

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas M. Saba
    • 1
  1. 1.Department of PhysiologyAlbany Medical College of Union UniversityAlbanyUSA

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