Fibronectin and Reticuloendothelial Clearance of Blood-Borne Particles Clinical Studies in Septic Shock

  • Thomas M. Saba


Sepsis in patients following blunt trauma, burn, and major surgery is etiologic in the high incidence of organ dysfunction as well as morbidity and mortality (Fulton and Jones, 1975; Saba et al., 1980; Saba and Jaffe, 1980). Indeed, even with modern surgical techniques, advances in antimicrobial therapy, and sophisticated patient monitoring, the death rate in the severely injured patient is very high due to the delayed development of organ failure with the onset of severe sepsis (Scovill et al., 1978; Saba and Jaffe, 1980; Powers and Saba, 1981). Recent data suggest that this may be related to organ microembolization and diffuse altered vascular permeability coupled with failure of reticuloendothelial host defense mechanisms.


Kupffer Cell Bacterial Sepsis Plasma Fibronectin Traumatic Shock Opsonic Activity 
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  1. Alitalo, K., Hovi, T., and Vaheri, A., 1980, Fibronectin is produced by human macrophages, J. Exp. Med. 151:602.PubMedCrossRefGoogle Scholar
  2. Allen, C., Saba, T. M., and Molnar, J., 1973, Isolation, purification and characterization of opsonic protein, J. Reticuloendothel. Soc. 13:10.Google Scholar
  3. Altura, B. M., and Hershey, S. G., 1973, Reitculoendothelial function in experimental injury and tolerance to shock, Adv. Exp. Med. Biol. 33:545.Google Scholar
  4. Annest, S. J., Scovill, W. A., Blumenstock, F. A., Stratton, H. H., Newell, J. C., Paloski, W. H., Saba, T. M., and Powers, S. R., 1980, Increased creatinine clearance following cyroprecipitate infusion in trauma and surgical patients with decreased renal function, J. Trauma 20:726.PubMedCrossRefGoogle Scholar
  5. Aschoff, L., 1924, Reticuloendothelial system, in: Lectures on Pathology, pp. 1–33, Harper & Row (Hoeber), New York.Google Scholar
  6. Benacerraf, B., Biozzi, G., Halpern, B. N., and Stiffel, C., 1957, Physiology of phagocytosis of particles by the RES, in: Physiology of the Reticuloendothelial System (D. N. Halpern, ed.), pp. 52–79, Thomas, Springfield, Ill.Google Scholar
  7. Blumenstock, F. A., and Saba, T. M., 1978, Purification of alpha-2-opsonic glycoprotein from human serum and its measurement by immunoassay, J. Reticuloendothel. Soc. 23:119.PubMedGoogle Scholar
  8. Blumenstock, F. A., Saba, T. M., Weber, P., and Cho, E., 1976, Purification and biochemical characterization of a macrophage stimulating alpha-2-globulin opsonic protein, J. Reticuloendothel. Soc. 19:157.PubMedGoogle Scholar
  9. Blumenstock, F. A., Weber, P. B., and Saba, T. M., 1977a, Isolation and purification from rat serum of an alpha-2-opsonic glycoprotein, J. Biol. Chem. 252:7156.Google Scholar
  10. Blumenstock, F. A., Weber, P., Saba, T. M., and Laffin, R., 1977b, Electroimmunoassay of alpha-2-opsonic protein during reticuloendothelial blockade, Am. J. Physiol. 232:R80.Google Scholar
  11. Blumenstock, F. A., Saba, T. M., Weber, P., and Laffin, R., 1977c, Physiological function for human cold-insoluble globulin: Identity with human opsonic α2-SB glycoprotein, J. Reticuloendothel. Soc. 22:35a.Google Scholar
  12. Blumenstock, F. A., Saba, T. M., Weber, P., and Laffin, R., 1978, Biochemical and immunological characterization of human opsonic α2SB glycoprotein: Its identity with cold-soluble globulin, J. Biol. Chem. 253:4287.PubMedGoogle Scholar
  13. Blumenstock, F. A., Saba, T. M., and Weber, P., 1979, An affinity method for rapid purification of opsonic α2-SB glycoprotein, Adv. Shock Res. 2:55.PubMedGoogle Scholar
  14. Blumenstock, F. A., Saba, T. M., Roccario, E., Cho, E., and Kaplan, J. E., 1981, Opsonic fibronectin after trauma and particle injection as determined by a peritoneal macrophage monolayer assay, J. Reticuloendothel. Soc. 30:61.PubMedGoogle Scholar
  15. Brodin, B., Berghem, L., Friberg-Nielson, S., Nordstrom, H., and Schildt, B., 1980, Fibronectin in the treatment of septicemia—A preliminary report, in: 7th World Congress of Anesthesiologists, p. 504, Excerpta Medica, Amsterdam.Google Scholar
  16. Cornell, R. P., 1980, Mechanism of acute hyperinsulinemia after Kupffer cell phagocytosis, Am. J. Physiol. 238:E276.PubMedGoogle Scholar
  17. Dillon, B. C., and Saba, T. M., 1980, Influence of fibronectin deficiency and reticuloendothelial blockade on intestinal transvascular fluid and protein flux during bacteremia, Surg. Forum 31:76.Google Scholar
  18. Dillon, B. C., and Saba, T. M., 1982, Fibronectin deficiency and intestinal transvascular fluid balance during bacteremia, Am. J. Physiol. 242:H557.PubMedGoogle Scholar
  19. Doran, J. E., Mansberger, A. R., and Reese, A. C., 1980, Cold-insoluble globulin enhanced phagocytosis of gelantinized targets by macrophage monolayers: A model system, J. Reticuloendothel. Soc. 27:471.PubMedGoogle Scholar
  20. Engvall, E., and Ruoslahti, E., 1977, Binding of soluble form of fibroblast surface protein, fibronectin to collagen, Int. J. Cancer 20:1.PubMedCrossRefGoogle Scholar
  21. Engvall, E., Ruoslahti, E., and Miller, E. J., 1977, Affinity of fibronectin to collagens of different genetic types and to fibrinogen, J. Exp. Med. 147:1584.CrossRefGoogle Scholar
  22. Evans, J. W., and Wagner, P. D., 1977, Limits on \({\dot V_A}/\dot Q\) distribution from analysis of experimental inert gas elimination, J. Appl. Physiol. 42:889.PubMedGoogle Scholar
  23. Filkins, J. P., 1971, Detoxification by leukocytes and macrophages, Proc. Soc. Exp. Biol. Med. 137:1396.PubMedGoogle Scholar
  24. Filkins, J. P., and Buchanan, B. J., 1977, Depression of RES function and altered glucoregulation, J. Reticuloendothel. Soc. 21:391.PubMedGoogle Scholar
  25. Filkins, J. P., Chase, R. E., and Smith, J. J., 1965, Characteristics of a plasma factor governing carbon phagocytosis in the isolated perfused rat liver, J. Reticuloendothel. Soc. 2:287.PubMedGoogle Scholar
  26. Fine, J., Rutenberg, S., and Schweinberg, P. B., 1959, The role of the RES in hemorrhagic shock, J. Exp. Med. 110:547.PubMedCrossRefGoogle Scholar
  27. Fulton, R. L., and Jones, E. G., 1975, The etiology of post-traumatic pulmonary insufficiency in man, Rev. Surg. 32:84.PubMedGoogle Scholar
  28. Gahmberg, C. G., and Hakamori, S., 1973, Altered growth behavior of malignant cells associated with changes in externally labelled glycoprotein and glycolipid, Proc. Natl. Acad. Sci. USA 70:3329.PubMedCrossRefGoogle Scholar
  29. Gans, H., 1966, Preservation of vascular patency as a function of reticuloendothelial clearance, Surgery 60:1216.PubMedGoogle Scholar
  30. Gans, H., and Lowman, J., 1967, Uptake of fibrin and fibrin degradation products by the isolated perfused rat liver, Blood 29:526.PubMedGoogle Scholar
  31. Gudewicz, P., Molnar, J., Lai, M. Z., Beezhold, D. W., Siefring, G. E., Jr., Credo, R. B., and Lorand, L., 1980, Fibronectin-mediated uptake of gelatin-coated latex particles by peritoneal macrophages, J. Cell Biol. 87:427.PubMedCrossRefGoogle Scholar
  32. Hayman, E. G., and Ruoslahti, E., 1979, Distribution of fetal bovine serum fibronectin and endogenous rat cell fibronectin in extracellular matrix, J. Cell Biol. 83:255.PubMedCrossRefGoogle Scholar
  33. Hoffstein, S. T., 1979, Ultrastructural and immunofluorescent detection of fibronectin associated with the surface coat of human blood neutrophils (PMN), J. Cell Biol. 83:699.Google Scholar
  34. Hynes, R. O., Ali, I. U., Destree, A. J., Mautner, V., Perkins, M. E., Senger, D. R., Wagner, D. D., and Smith, K. K., 1978, A large glycoprotein lost from the surface of transformed cells, Ann. N.Y. Acad. Sci. 312:317.PubMedCrossRefGoogle Scholar
  35. Jaffe, E. A., and Mosher, M. F., 1978a, Synthesis of fibronectin by cultured human endothelial cells, J. Exp. Med. 147:1779.CrossRefGoogle Scholar
  36. Jaffe, E. A., and Mosher, M. F., 1978b, Synthesis of fibronectin by cultured human endothelial cells, Ann. N.Y. Acad. Sci. 213:122.CrossRefGoogle Scholar
  37. Johansson, S., Rubin, C., Hook, H., Ahldren, T., and Seljelid, R., 1979, In vitro biosynthesis of cold-insoluble globulin (fibronectin) by mouse peritoneal macrophages, FEBS Lett. 105:313.PubMedCrossRefGoogle Scholar
  38. Kaplan, J. E., 1981, The role of the reticuloendothelial system in control of hemostatic and thrombotic mechanisms, in: Pathophysiology of the Reticuloenthelial System (B. M. Altura and T. M. Saba, eds.), pp. 111–129, Raven Press, New York.Google Scholar
  39. Kaplan, J. E., and Saba, T. M., 1976, Humoral deficiency and reticuloendothelial depression after traumatic shock, Am. J. Physiol. 230:7.PubMedGoogle Scholar
  40. Kaplan, J. E., and Snedeker, P. W., 1980, Maintenance of fibrin solubility by plasma fibronectin, J. Lab. Clin. Med. 96:1054.PubMedGoogle Scholar
  41. Kaplan, J. E., Saba, T. M., and Cho, E., 1976, Serological modifications of reticuloendothelial capacity and altered resistance to traumatic shock, Circ. Shock 2:203.Google Scholar
  42. Keski-Oja, J., Sen, A., and Todaro, G. J., 1979, Direct association of fibronectin and actin molecules in vitro, J. Cell Biol. 581:237.Google Scholar
  43. Kuusela, P., 1978, Fibronectin binds to Staphylococcus aureus, Nature (London) 276:718.CrossRefGoogle Scholar
  44. Lanser, M. E., and Saba, T. M., 1981, Fibronectin as a co-factor necessary for optimal granulocyte phagocytosis of Staphylococcus aureus, J. Reticuloendothel. Soc. 30:415.PubMedGoogle Scholar
  45. Lanser, M. E., Saba, T. M., and Scovill, W. A., 1980, Opsonic glycoprotein (plasma fibronectin) levels after burn injury: Relationship to extent of burn and development of sepsis, Ann. Surg. 192:776.PubMedCrossRefGoogle Scholar
  46. Linder, E., Vaheri, A., Ruoslahti, E., and Wartiovaara, J., 1975, Distribution of fibroblast surface antigen in the developing chick embryo, J. Exp. Med. 142:41.PubMedCrossRefGoogle Scholar
  47. Macarak, E. J., Kirby, E., Kirk, T., and Kefalides, N. A., 1978, Synthesis of cold-insoluble globulin by cultured calf endothelial cells, Proc. Natl. Acad. Sci. USA 75:2621.PubMedCrossRefGoogle Scholar
  48. McDonald, J. A., Baum, B. J., Rosenberg, D. M., Kalman, J. A., Brin, S. C., and Crystal, R. G., 1979, Destruction of a major extra vascular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leukocyte granules, Lab. Invest. 40:350.PubMedGoogle Scholar
  49. Malik, A. B., and van der Zee, H., 1978a, Lung vascular permeability following progressive pulmonary microembolization, J. Appl. Physiol. 45:590.Google Scholar
  50. Malik, A. B., and van der Zee, H., 1978b, Mechanism of pulmonary edema induced by microembolization, Circ. Res. 42:72.Google Scholar
  51. Metchnikoff, E., 1905, Immunity in Infective Diseases (F. G. Binnie, transl.), Cambridge University Press, London.Google Scholar
  52. Molnar, J., Mclain, L., Allan, C., Laga, H., Gava, A., and Gelder, R., 1977, Specificity of a non- complement related opsonic protein, Biochim. Biophys. Acta 433:37.Google Scholar
  53. Molnar, J., Gelder, F. B., Zong, I. M., Siegring, G. E., Credo, B. B., and Lorand, L., 1979, Purification of opsonically active human and rat cold-insoluble globulin (plasma fibronectin), Biochemistry 18:3909.PubMedCrossRefGoogle Scholar
  54. Morrison, P. R., Edsall, J. T., and Miller, S. G., 1948, Preparation and properties of serum and plasma proteins. XVIII. The separation of purified fibrinogen from fraction I of human plasma, J. Am. Chem. Soc. 70:3103.PubMedCrossRefGoogle Scholar
  55. Mosesson, M. W., 1972, Cold-insoluble globulin (CIg): A circulating cell surface protein, Thomb. Haemostasis 38:742.Google Scholar
  56. Mosesson, M. W., and Umfleet, R. A., 1970, The cold-insoluble globulin of human plasma. I. Purification, primary characterization and relationship to fibrinogen and other cold-insoluble fraction components, J. Biol. Chem. 245:5728.PubMedGoogle Scholar
  57. Mosher, D. F., 1976a, Action of fibrin-stabilizing factor on cold-insoluble globulin and α2 macroglobulin in clotting plasma, J. Biol. Chem. 251:1639.Google Scholar
  58. Mosher, D. F., 1976b, Cross linking of cold-insoluble globulin by fibrin-stabilizing factor, J. Biol. Chem. 250:6614.Google Scholar
  59. Mosher, D. F., 1980, Fibronectin, Prog. Hemostasis Thromb. 5:111.Google Scholar
  60. Mosher, D. F., and Proctor, R. A., 1980, Binding and factor XIII-mediated crosslinking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus, Science 209:927.PubMedCrossRefGoogle Scholar
  61. Mosher, D. F., and Williams, E. M., 1978, Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intravascular coagulation, J. Lab. Clin. Med. 91:729.PubMedGoogle Scholar
  62. Niehaus, G. D., Schumacker, P., and Saba, T. M., 1980a, Influence of opsonic fibronectin deficiency on lung fluid balance during bacterial sepsis, J. Appl. Physiol. Respir. Environ. Exercise Physiol. 49:693.Google Scholar
  63. Niehaus, G. D., Schumacker, P., and Saba, T. M., 1980b, Reticuloendothelial clearance of blood-borne particulates, Ann. Surg. 191:479.CrossRefGoogle Scholar
  64. Oh, E., Pierschbacher, M., and Ruoslahti, E., 1981, Deposition of plasma fibronectin in tissues, Proc. Natl. Acad. Sci. USA 78:3218.PubMedCrossRefGoogle Scholar
  65. Olcay, L., Holper, K., Kitahama, A., Miller, R. H., Drapanas, T., and Trejo, R. A., 1974, Reticuloendothelial function: Determinant for survival following hepatic ischemia in the baboon, Surgery 76:643.PubMedGoogle Scholar
  66. Owens, M. R., and Cimino, C. D., 1982, Synthesis of fibronectin by the isolated perfused rat liver, Blood 59:1305.PubMedGoogle Scholar
  67. Palmer, D. L., Rifkind, D., and Brown, D. W., 1971a, 131I-labeled colloidal human albumin in the study of reticuloendothelial system function. III. Phagocytic catabolism compared in normal, leukemic, and immunosuppressed human subjects, Infect. Dis. 123:465.CrossRefGoogle Scholar
  68. Palmer, D. L., Rifkind, D., and Brown, D. W., 1971b, 131I-labeled colloidal human serum albumin in the study of reticuloendothelial system function. II. Phagocytosis and catabolism of a test colloid in normal subjects, J. Infect. Dis. 123:457.CrossRefGoogle Scholar
  69. Pearlstein, E., Gold, L. I., and Garcia-Pardo, A., 1980, Fibronectin: A review of structure and biological activity, Mol. Cell. Biochem. 29:103.PubMedCrossRefGoogle Scholar
  70. Powers, S. R., and Saba, T. M., 1981, Organ failure in sepsis, in: Surgical Infectious Diseases (R. L. Simmons and R. Howard, eds.), pp. 339–358, Appleton-Century-Crofts, New York.Google Scholar
  71. Proctor, R. A., Prendergast, E., and Mosher, D. F., 1979, Opsonization of bacteria by fibronectin, Clin. Res. 27:650A.Google Scholar
  72. Robbins, A. B., Doran, J. E., Reese, A. C., and Mansberger, A. R., 1980, Cold-insoluble globulin levels in operative trauma: Serum depletion, wound sequestration, and biological activity, Am. Surg. 46:663.PubMedGoogle Scholar
  73. Roccario, E., Saba, T. M., and Cho, E., 1981, Humoral regulation of plasma opsonic fibronectin levels: Its role in reticuloendothelial recovery after RE blockade, Adv. Shock Res. 5:57.PubMedGoogle Scholar
  74. Rogers, D. E., 1960, Host mechanisms which act to remove bacteria from the blood stream, Bateriol. Rev. 24:50.Google Scholar
  75. Ruoslahti, E., and Vaheri, A., 1975, Interaction of soluble fibroblast surface antigen with fibrinogen and fibrin: Identity with cold-insoluble globulin of human plasma, J. Exp. Med. 141:497.PubMedCrossRefGoogle Scholar
  76. Saba, T. M., 1970, Physiology and pathophysiology of the reticuloendothelial system, Arch. Intern. Med. 126:1031.PubMedCrossRefGoogle Scholar
  77. Saba, T. M., 1972, Effect of surgical trauma on the clearance and localization of blood-borne particulate matter, Surgery 71:675.PubMedGoogle Scholar
  78. Saba, T. M., 1975, Reticuloendothelial systemic host-defense after surgery and traumatic shock, Circ. Shock 2:91.Google Scholar
  79. Saba, T. M., 1979, Reversing multiple organ failure, J. Trauma Suppl. 19:883.Google Scholar
  80. Saba, T. M., and Cho, E., 1979, Reticuloendothelial systemic response to operative trauma as influenced by cryoprecipitate or cold-insoluble globulin therapy, J. Reticuloendothel. Soc. 26:171.PubMedGoogle Scholar
  81. Saba, T. M., and DiLuzio, N. R., 1965, Kupffer cell phagocytosis and metabolism of particles as a function of opsonization, J. Reticuloendothel. Soc. 2:437.PubMedGoogle Scholar
  82. Saba, T. M., and DiLuzio, N. R., 1969, Reticuloendothelial blockade and recovery as a function of opsonic activity, Am. J. Physiol. 216:197.PubMedGoogle Scholar
  83. Saba, T. M., and Jaffe, E., 1980, Plasma fibronectin (opsonic glycoprotein): Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function, Am. J. Med. 68:577.PubMedCrossRefGoogle Scholar
  84. Saba, T. M., Filkins, J. P., and DiLuzio, N. R., 1966, Properties of the “opsonic system” regulating in vitrohepatic phagocytosis, J. Reticuloendothel. Soc. 3:398.Google Scholar
  85. Saba, T. M., Blumenstock, F. A., Bernard, H., and Kaplan, J. E., 1977, Prevention of reticuloendothelial depression following surgery by intravenous opsonic glycoprotein therapy, J. Reticuloendothel. Soc. 22:16a.Google Scholar
  86. Saba, T. M., Blumenstock, F. A., Scovill, W. A., and Bernard, H., 1978a, Cryoprecipitate reversal of opsonic α2 surface binding glycoprotein deficiency in septic surgical and trauma patients, Science 201:622.CrossRefGoogle Scholar
  87. Saba, T. M., Blumentsock, F. A., Weber, P., and Kaplan, J. E., 1978b, Physiologic role for cold-insoluble globulin in systemic host defense: Implications of its characterization as the opsonic α2SB glycoprotein, Ann. N.Y. Acad. Sci. 312:43.CrossRefGoogle Scholar
  88. Saba, T. M., Scovill, W. A., and Powers, S. R., 1980, Human host defense mechanisms as they relate to surgery and trauma, Surg. Ann. 12:1–20.Google Scholar
  89. Saba, T. M., Albert, W. H., Blumenstock, F. A., Evanega, G., Staehler, F., and Cho, E., 1981, Evaluation of a rapid immunoturbidimetric assay for opsonic plasma fibronectin in surgical and trauma patients, J. Lab. Clin. Med. 98:482.PubMedGoogle Scholar
  90. Saba, T. M., Niehaus, G. D., and Dillon, B. C., Reticuloendothelial response to shock and trauma: Its relationship to disturbances in fibronectin and cardiopulmonary function, 1981, in: Pathophysiology of the Reticuloendothelial System (B. M. Altura and T. M. Saba, eds.), pp. 131–157, Raven Press, New York.Google Scholar
  91. Salky, N. K., DiLuzio, N. R., P’Pool, D. B., and Sutherland, A. J., 1964, Evaluation of reticuloendothelial function in man, J. Am. Med. Assoc. 187:744 - 748.Google Scholar
  92. Salky, N. K., DiLuzio, N. R., Levin, A. G., and Goldsmith, A. S., 1967, Phagocytic activity of the reticuloendothelial system in neoplastic disease, Lab. Clin. Med. 70393–403.Google Scholar
  93. Schildt, B., Gertz, I., and Wide, L., 1974, Differentiated reticuloendothelial system (RES) function in some critical surgical conditions, Acta Chir. Scand. 140:611.PubMedGoogle Scholar
  94. Schumacker, P. T., and Saba, T. M., 1980, Pulmonary gas exchange abnormalities during intravascular coagulation: Reticuloendothelial involvement, Ann. Surg. 192:95.PubMedCrossRefGoogle Scholar
  95. Scovill, W. A., Saba, T. M., Kaplan, J. E., Bernard, H., and Powers, S., 1976, Deficits in reticuloendothelial humoral control mechanisms in patients after trauma, J. Trauma 16:898.PubMedCrossRefGoogle Scholar
  96. Scovill, W. A., Saba, T. M., Kaplan, J. E., Bernard, H. R., and Powers, S. R., 1977, Disturbances in circulating opsonic activity in man after operative and blunt trauma, J. Surg. Res. 22:709.PubMedCrossRefGoogle Scholar
  97. Scovill, W. A., Saba, T. M., Blumenstock, F. A., Bernard, H., and Powers, S. R., 1978, Opsonic α2 surface binding glycoprotein therapy during sepsis, Ann. Surg. 188:521.PubMedCrossRefGoogle Scholar
  98. Scovill, W. A., Annest, S., Saba, T. M., Blumenstock, F. A., Newell, J. C., Stratton, H. H., and Powers, S. R., 1979, Cardiovascular hemodynamics after opsonic α2SB glycoprotein therapy in injured patients, Surgery 86:284.PubMedGoogle Scholar
  99. Sherman, L. A., and Lee, J., 1977, Specific binding of soluble fibrin to macrophages, J. Exp. Med. 145:76.PubMedCrossRefGoogle Scholar
  100. Sherman, L. A., and Lee, J., 1979, Fibronectin: Its blood clearance and interaction with fibrin in vivo, Thromb. Haemostasis 42:121.Google Scholar
  101. Snyder, E. L., Mosher, D. F., Hezzey, A., Bock, J., and Golenwsky, G., 1980, Effect of blood transfusion on plasma fibronectin, Anesthesiology 53:S191.CrossRefGoogle Scholar
  102. Stenman, S., and Vaheri, A., 1978, Distribution of a major connective tissue protein, fibronectin, in normal human tissues, J. Exp. Med. 147:1054.PubMedCrossRefGoogle Scholar
  103. Wright, A. E., and Douglas, S. R., 1903, An experimental investigation of the role of the blood fluids in connection with phagocytosis, Proc. R. Soc. 72:357.CrossRefGoogle Scholar
  104. Yamada, K. M., and Kennedy, D. W., 1979, Fibroblast cellular and plasma fibronectin are similar but not identical, J. Cell Biol. 80:492.PubMedCrossRefGoogle Scholar
  105. Yamada, K. M., and Olden, K., 1978, Fibronectins: Adhesive glycoproteins of cell surface and blood, Nature (London) 275:179.CrossRefGoogle Scholar
  106. Yelich, M. R., and Filkins, J. P., 1980, Mechanisms of hyperinsulinemia in endotoxicosis, Am. J. Physiol. 239:E156.PubMedGoogle Scholar
  107. Zweifach, B. W., Benacerraf, B., and Thomas, L., 1957, Relationships between the vascular manifestations of shock produced by endotoxin, trauma and hemorrhage. II. The possible role of the RES in resistance to each type of shock, J. Exp. Med. 106:403.PubMedCrossRefGoogle Scholar

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© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas M. Saba
    • 1
  1. 1.Department of PhysiologyAlbany Medical College of Union UniversityAlbanyUSA

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