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Modulation of the Efflux of Anticancer Agents

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Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches

Part of the book series: Developments in Oncology ((DION,volume 47))

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Abstract

The development of cellular drug resistance seems a unique characteristic of cancerous tissues. In addition, drug resistant cancer cells often express cross resistance to other structurally unrelated anticancer agents. In order to elucidate the etiology of drug resistance, many possible mechanisms have been proposed and examined, including the development of a membrane barrier (1, 2, 3, 4), gene amplification (5, 6, 7), enhanced drug degradation (8), loss of drug activation ability (9), repair of DNA damage (10, 11) and other genetic or epigenetic possibilities (12, 13, 14).

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Authors
  1. Ta-hsu Chou
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Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Frederick A. Valeriote  & Laurence H. Baker  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Chou, Th. (1986). Modulation of the Efflux of Anticancer Agents. In: Valeriote, F.A., Baker, L.H. (eds) Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches. Developments in Oncology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2331-0_15

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  • DOI: https://doi.org/10.1007/978-1-4613-2331-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9432-0

  • Online ISBN: 978-1-4613-2331-0

  • eBook Packages: Springer Book Archive

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