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Issues in Supportive Care of Cancer Patients pp 1–13Cite as

Hematologic disorders associated with cancer: I. Red blood cell disorders

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 30))

Abstract

Anemia is the most common hematologic abnormality in patients with cancer. Anemia can be defined in several ways including: (1) decrease in red blood cell count, hemoglobin, or hematocrit (concentration measurements); (2) decrease in the red cell volume or Cr51 red cell mass. The mechanisms of cancer-related anemia are treated in detail in other reviews (1, 2).

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References

  1. Bateman LJT, Beard MEJ. 1976. Malignant disease. In: Haematologic Aspects of Systemic Disease. Israel MCG, Delamore IW (eds). Saunders, London, pp 131–161.

    Google Scholar 

  2. Doll DC, Weiss RB. 1985. Neoplasia and the erythron. J Clin Oncol 3:429–446.

    CAS  PubMed  Google Scholar 

  3. Eichner ER. 1979. Splenic function: Normal, too much and little. Am J Med 66:311–320.

    Article  CAS  PubMed  Google Scholar 

  4. Goldman JM, Nolasco I. 1983. The spleen in myeloproliferative disorders. Clin Haematol 12:505–516.

    CAS  PubMed  Google Scholar 

  5. Christinsen BE, Jonsson V, Videback A. 1983. The spleen in lymphoproliferative disorders. Clin Haematol 12:517–533.

    Google Scholar 

  6. Lynch EC, Alfrey CP Jr. 1965. Histiocytic medullary reticulosis. Hemolytic anemia due to erythrophagocytosis by histiocytes. Ann Intern Med 63:666–671.

    Article  CAS  PubMed  Google Scholar 

  7. Jaffe ES, Costa I, Fauci AS et al. 1983. Malignant lymphoma and erythophagocytosis simulating malignant histiocytosis. Am J Med 75:741–749.

    Article  CAS  PubMed  Google Scholar 

  8. Scott RB, Robb Smith AHT. 1939. Histiocytic medullary reticulosis. Lancet 2:194–198.

    Article  Google Scholar 

  9. Cartwright GE. 1966. The anemia of chronic disorders. Sem Hematol 3:351–373.

    CAS  Google Scholar 

  10. Cartweight GE, Lee GR. 1971. The anemia of chronic disease. Br J Haematol 21:147–152.

    Article  Google Scholar 

  11. Hyman GA, Gelhorn A, Harray J. 1956. Studies of the anemia of disseminated malignant neoplastic disease. II. Study of the life span of the erythrocyte. Blood 11:618–631.

    CAS  PubMed  Google Scholar 

  12. Douglas SW, Adamson JW. 1975. The anemia of chronic disorders: Studies of marrow regulation and iron metabolism. Blood 45:55–65.

    CAS  PubMed  Google Scholar 

  13. Dumick N, Kalkami V, Howard D et al. 1983. Mechanisms of abnormal erythropoiesis in malignancy. Cancer 51:1101–1106.

    Article  Google Scholar 

  14. Chanarin I. 1976. Investigation and management of megaloblastic anemia. Clin Haematol 5:747–763.

    Google Scholar 

  15. Krantz S. 1974. Pure red cell aplasia. N Engl J Med 291:345–350.

    Article  CAS  PubMed  Google Scholar 

  16. Krantz, S. 1976. Diagnosis and treatment of pure red cell aplasia. Med Clin North Am 60:945–958.

    CAS  PubMed  Google Scholar 

  17. Hirst E, Robertson TE. 1967. The syndrome of thymoma and erythroblastopenic anemia — A review of 56 cases. Medicine 46:225–264.

    Article  CAS  PubMed  Google Scholar 

  18. Sieff C. 1983. Pure red cell aplasia. Br J Haematol 54:331–336.

    Article  CAS  PubMed  Google Scholar 

  19. Mitchell ABS, Pinn G, Pegrum GD. 1971. Pure red cell aplasia and carcinoma. Blood 37:594–597.

    CAS  PubMed  Google Scholar 

  20. Slater LM, Schultz MJ, Armentrout SA. 1974. Remission of pure red cell aplasia associated with non thymic malignancy. Cancer 44:1879–1881.

    Article  Google Scholar 

  21. Natelson EA, Lynch EC, Hettig RA, Alfrey CP. Jr. 1968. Histiocytic medullary reticulosis. Arch Intern Med 122:223–229.

    Article  CAS  PubMed  Google Scholar 

  22. Tseng A Jr, Coleman CN, Cox RS et al. 1984. The treatment of malignant histiocytosis. Blood 64:48–53.

    PubMed  Google Scholar 

  23. Dacie JV. 1975. Autoimmune haemolytic anemia. Arch Intern Med 135:1293–1306.

    Article  CAS  PubMed  Google Scholar 

  24. Jones JE. 1973. Autoimmune disorders and malignant lymphoma. Cancer 31:1092–1098.

    Article  CAS  PubMed  Google Scholar 

  25. Worlledge SH. 1978. The interpretation of a positive direct antiglobulin test. Br J Haematol 38:157–162.

    Article  Google Scholar 

  26. Sokol RJ, Hewitt S, Stamps BK. 1981. Autoimmune hemolytic anemia: An 18 year study of 865 cases referred to a regional transfusion center. Br Med J 282:2023–2027.

    Article  CAS  Google Scholar 

  27. Kyle RA, Kiely JM, Stickney JM. 1959. Acquired hemolytic anemia in chronic lymphocytic leukemia and the lymphomas. Arch Intern Med 104:61–67.

    Article  CAS  Google Scholar 

  28. Eisner E, Ley AB, Meyer K. 1967. Coombs-positive hemolytic anemia in Hodgkin’s disease. Ann Intern Med 66:258–273.

    Article  CAS  PubMed  Google Scholar 

  29. Levine AM, Thornton P, Forman SJ et al. 1980. Positive Coombs test in Hodgkin’s disease: Significance and implications. Blood 55:607–611.

    CAS  PubMed  Google Scholar 

  30. Garraty G, Petz LD, Wallerstein RO, Fudenberg HH. 1974. Autoimmune hemolytic anemia in Hodgkin’s disease associated with anti-It. Transfusion 14:226–231.

    Article  Google Scholar 

  31. Crisp D, Pruzanski W. 1982. B-cell neoplasms with homogenous cold-reacting antibodies (cold agglutinin). Am J Med 72:915–922.

    Article  CAS  PubMed  Google Scholar 

  32. Pruzanski W, Shumak KH 1977. Biologic activity of cold reacting autoantibodies. N Engl J Med 297:578–592.

    Article  Google Scholar 

  33. Brain MC. 1970. Microangiopathic hemolytic anemia. Ann Rev Med 21:133–144.

    Article  CAS  PubMed  Google Scholar 

  34. Lohrmann HP, Adam W, Heymer B, Kubanek A. 1973. Microangiopathic hemolytic anemia in metastatic carcinoma. Ann Intern Med 79:368–375.

    Article  CAS  PubMed  Google Scholar 

  35. Brain MC. 1972. Microangiopathic hemolytic anemia. Br J Haematol 23:45–52.

    Article  PubMed  Google Scholar 

  36. Antman KH, Skarin AT, Mayer RJ, Hargraves HK, Canellos GP. 1979. Microangiopathic hemolytic anemia and cancer: A review. Medicine 58:377–384.

    Article  CAS  PubMed  Google Scholar 

  37. Alpert LI, Benisch B. 1970. Hemangioendothelioma of the liver associated with microangiopathic hemolytic anemia. Report of four cases. Am J Med 48:624–628.

    Article  CAS  PubMed  Google Scholar 

  38. Davis S, Rambotti P, Grignoni F. 1985. Microangiopathic hemolytic anemia and pulmonary small cell carcinoma. Ann Intern Med 103:638.

    Article  CAS  PubMed  Google Scholar 

  39. Cantrell JE, Phillips TM, Schein PS. 1985. Carcinoma-associated hemolytic anemia syndrome: A complication of Mitomycin C chemotherapy. J Clin Oncol 3:723–734.

    PubMed  Google Scholar 

  40. Price TM, Murgo AJ, Keveney JJ et al. 1985. Renal failure and hemolytic anemia associated with Mitomycin C. A case report. Cancer 55:51–56.

    Article  CAS  PubMed  Google Scholar 

  41. Clifford GO. 1966. The clinical significance of leucoerythroblastic anemia. Med Clin North Am 50:789–799.

    Google Scholar 

  42. Ehmen L. 1976. Bone marrow biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am J Med 60:1–7.

    Article  Google Scholar 

  43. Valentine WN, Hennessey TC, Lang E et al. 1968. Polycythemia, erythrocytosis, and erythemia. Ann Intern Med 69:587–606.

    Article  Google Scholar 

  44. Daman A, Holub DA, Medicow MM et al. 1958. Polycythemia and renal carcinoma: Report of ten new cases, two with long standing hematologic remission following nephrectomy. Am J Med 25:182–197.

    Article  Google Scholar 

  45. Tso SC, Hua ASP. 1974. Erythrocytosis in hepatocellular carcinoma. Br J Haematol 28:497–503.

    Article  CAS  PubMed  Google Scholar 

  46. Waldmann TA, Levin EH, Baldwin M. 1961. The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoietin stimulating factor by the tumor. Am J Med 31:318–324.

    Article  CAS  PubMed  Google Scholar 

  47. Lipsett MB, Odell WD, Rosenberg E, Waldmann TA. 1964. Numoral syndromes associated with nonendocrine tumors. Ann Intern Med 61:733.

    Article  CAS  PubMed  Google Scholar 

  48. Adamson JW, Finch CA. 1968. Erythropoietin and the polycythemias. Ann. NY Acad Sci 149:560–568.

    Article  CAS  PubMed  Google Scholar 

  49. Waldmann TA, Rosse WF, Swann RI. 1968. The erythropoietin-stimulating factors produced by tumors. Ann NY Acad Sci 149:509–515.

    Article  CAS  PubMed  Google Scholar 

  50. Hammond A, Winnick A. 1974. Paraneoplastic erythrocytosis and ectopic erythropoietin. Ann NY Acad Sci 230:219–227.

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. William M. Davis
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Editors and Affiliations

  1. Baystate Medical Center, Springfield, MA, 01199, USA

    Donald J. Higby M.D. (Chief Hematology/Oncology Service) (Chief Hematology/Oncology Service)

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© 1986 Martinus Nijhoff Publishers, Boston

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Davis, W.M. (1986). Hematologic disorders associated with cancer: I. Red blood cell disorders. In: Higby, D.J. (eds) Issues in Supportive Care of Cancer Patients. Cancer Treatment and Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2325-9_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2325-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9429-0

  • Online ISBN: 978-1-4613-2325-9

  • eBook Packages: Springer Book Archive

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