Abstract
We present an update in our ongoing studies to describe the structures of rat brain mRNAs, elucidate the mechanisms of their tissue-specific control, and identify and characterize their protein products. Here we discuss 1) mRNAs encoding a probable precursor of a neurotran-smitter that functions in olfactory, somatosensory, limbic, auditory and motor systems, 2) mRNAs encoding myelin proteolipid protein, and 3) a polymorphic family of 88 mRNAs transcribed from a single gene. We show that primate and rodent share many brain proteins and that approximately 5,000 to 10,000 genes are first expressed after birth. The developmental regulation of these genes may be controlled by identifier sequences, a neuronal enhancer.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Milner, R.J. and Sutcliffe, J.G. Nucleic Acids Res. 11(16): 5497–5520, 1983.
Sutcliffe, J.G., Milner, R.J., Shinnick, T.M. and Bloom, F.E. Cell 33: 671–682, 1983.
Sutcliffe, J.G., Milner, R.J. and Bloom, F.E. Cold Spring Harbor Symp. Quant. Biol. 48: 477–484, 1983.
Bloom, F.E., Battenberg, E.L.F., Milner, R.J. and Sutcliffe, J.G. J. Neurosci. 5: 1781–1802, 1985.
Lenoir, D., Battenberg, E., Kiel, M., Bloom, F.E. and Milner, R.J. J. Neurosci. (in press).
Malfroy, B., Bakhit, C., Bloom, F.E., Sutcliffe, J.G. and Milner, R.J. Proc. Natl. Acad. Sci. USA 82: 2009, 1985.
Milner, R.J., Bloom, F.E., Lai, C., Lerner, R.A. and Sutcliffe, J.G. Proc. Natl. Acad. Sci. USA 81: 713–717, 1984.
Fitting, T., Danielson, P., McKinnon, R.D., Tsou, A.-P. and Sutcliffe, J.G. (in preparation).
Milner, R.J., Lai, C., Nave, K., Lenoir, D., Ogata, J., Bloom, F.E. and Sutcliffe, J.G. Cell 42: 931–939, 1985.
Tsou, A.-P., Lai, C., Danielson, P., Noonan, D. and Sutcliffe, J.G. J. Mol. Cell Biol. (in press).
Sutcliffe, J.G., Milner, R.J., Gottesfeld, J.M. and Reynolds, W. Science 225: 1308–1315, 1984.
Sutcliffe, J.G., Milner, R., Bloom, F.E. and Lerner, R.A. Proc. Natl. Acad. Sci. USA 79: 4942–4946, 1982.
Sutcliffe, J.G., Milner, R.J., Gottesfeld, J.M. and Lerner, R.A. Nature 308: 237–241, 1984.
McKinnon, R.D., Shinnick, T.M. and Sutcliffe, J.G. Science, submitted.
Kenney, S., Natarajan, V., Strike, D., Khoury, G. and Salzman, P. Science 226: 1337–1339, 1984.
Thomas, J.O. and Thompson, R.J. Cell 10: 633, 1977.
Brown, I.R. In: Handbook of Neurochemistry, 2nd edition (Ed. A. Lajtha), Plenum Press, New York, Vol. 5, 1983, pp. 217–226.
Brown, I.R. and Greenwood, P.D. In: Molecular Approaches to Neurobiology (Ed. I.R. Brown), Academic Press, New York, 1982, pp. 41–69.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Martinus Nijhoff Publishing
About this chapter
Cite this chapter
Sutcliffe, J.G., McKinnon, R.D., Tsou, AP. (1986). Gene Expression in the Mammalian Brain. In: Giuditta, A., Kaplan, B.B., Zomzely-Neurath, C. (eds) Role of RNA and DNA in Brain Function. Topics in the Neurosciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2321-1_3
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2321-1_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-89838-814-5
Online ISBN: 978-1-4613-2321-1
eBook Packages: Springer Book Archive