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Post-Translational Modifications of Chromosomal Proteins in Neuronal and Glial Nuclei from Developing Rat Brain

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Role of RNA and DNA in Brain Function

Part of the book series: Topics in the Neurosciences ((TNSC,volume 3))

Abstract

Post-translational modifications of nuclear proteins may induce changes in DNA-protein interactions, which modify DNA conformation and affect the binding of enzymes and proteins involved in gene regulation. Age-specific changes of acetylation, methylation and phosphorylation of histone and non-histone proteins have been found in cerebral hemispheres and cerebellum of rats at 10 and 30 days of age. Age-specific differences between neuronal and glial nuclei have also been noted, especially during the first period of postnatal development. These observations may be related to neuronal and glial cell differences in a) patterns of differentiation, b) chromatin structures, and c) transcription rate.

deceased August 25, 1985

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Authors and Affiliations

  1. Institute of Biochemistry, Faculty of Medicine, University of Catania, Italy

    I. Serra & A. M. Giuffrida

Authors
  1. I. Serra
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  2. A. M. Giuffrida
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Editor information

Editors and Affiliations

  1. Department of General and Environmental Physiology, University of Naples, Italy

    Antonio Giuditta

  2. Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA

    Barry B. Kaplan

  3. Office of Naval Research London Branch, UK

    Claire Zomzely-Neurath

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© 1986 Martinus Nijhoff Publishing

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Serra, I., Giuffrida, A.M. (1986). Post-Translational Modifications of Chromosomal Proteins in Neuronal and Glial Nuclei from Developing Rat Brain. In: Giuditta, A., Kaplan, B.B., Zomzely-Neurath, C. (eds) Role of RNA and DNA in Brain Function. Topics in the Neurosciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2321-1_16

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  • DOI: https://doi.org/10.1007/978-1-4613-2321-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-89838-814-5

  • Online ISBN: 978-1-4613-2321-1

  • eBook Packages: Springer Book Archive

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