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Anatomic and Surgical Principles in Cancer Clinical Trials

  • Chapter
Clinical Evaluation of Antitumor Therapy

Part of the book series: Developments in Oncology ((DION,volume 46))

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Abstract

A number of anatomic-surgical principles are important in the understanding of the natural history of malignant disease and emerge as important prognostic factors. This chapter will discuss the importance of these principles in the design and analysis of clinical trials. Anatomic aspects include the location and bulk of the tumor and the pattern of metastasis. These anatomic aspects often define which therapeutic modalities are potentially applicable and delineate the limits of therapy. Surgical participation in trials, necessary in the design and implementation of a trial, is needed in diagnosis, staging, follow-up, and therapy.

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Authors
  1. Thomas T. Kubota
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  2. William D. Dewys
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Editor information

Editors and Affiliations

  1. Norris Cancer Hospital, USC School of Medicine, USC Comprehensive Cancer Center, 1441 Eastlake Avenue, Room 162, Los Angeles, CA, 90033, USA

    Franco M. Muggia M.D.

  2. Pharmaceutical Research and Development Division, Bristol-Myers Company and New York University Medical Center, P.O. Box 4755, Syracuse, NY, 13221-4755, USA

    Marcel Rozencweig M.D.

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© 1987 Martinus Nijhoff Publishing, Boston

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Kubota, T.T., Dewys, W.D. (1987). Anatomic and Surgical Principles in Cancer Clinical Trials. In: Muggia, F.M., Rozencweig, M. (eds) Clinical Evaluation of Antitumor Therapy. Developments in Oncology, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2317-4_6

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  • DOI: https://doi.org/10.1007/978-1-4613-2317-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9425-2

  • Online ISBN: 978-1-4613-2317-4

  • eBook Packages: Springer Book Archive

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