Experimental Therapy: In Vitro Models

  • John D. Cowan
  • Daniel D. von Hoff
Part of the Developments in Oncology book series (DION, volume 46)


Cytotoxic agents have a key role in the treatment of cancer. Unfortunately, the effectiveness of these agents is limited, and their effect on an individual patient’s tumor is frequently difficult to predict. In an effort to improve the therapeutic results of cytotoxic chemical therapy, attempts have been made to develop an in vitro system to predict drug sensitivity in man, much as bacterial culture and sensitivity techniques are used to tailor antibiotic use. Such a system would allow (1) the rapid screening of potential antineoplastic agents, which would aid in the development of promising clinical trials; and (2) the selection of an appropriate chemotherapeutic agent or agents for an individual patient’s tumor.


Label Index Soft Agar Drug Sensitivity Clinical Correlation Cytosine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • John D. Cowan
  • Daniel D. von Hoff

There are no affiliations available

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