Appetitive Behavior May Serve as a Model For Studying The Neural Facilitation and Inhibition of Plasma Corticosterone Levels in Rats
Studies of the neural control of the hypothalamo-pituitary-adrenal system have frequently suggested the existence of a neural system that inhibits the corticotropin-releasing hormone (CRH) neurons of the hypothalamus. The most explicit proposals have suggested that the neural inhibition of CRH neurons is mediated by α-adrenergic (probably α 1) receptors  and neurons in the area of the ventromedial hypothalamic (VMH) nucleus . However, there is evidence that noradrenaline facilitates CRH neurons , and the general conception remains that CRH neurons are under predominantly facilitatory neural control while inhibition is predominantly or exclusively of a tonic, negative feedback nature. Most research on neural control of this system has used models focusing on basal levels and stress-induced activation.
KeywordsNoradrenaline Catecholamine Monoamine Corticosterone Yohimbine
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