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In Vivo Cardiovascular Responses to Isoproterenol, Dopamine, and Tyramine Following Prolonged Infusion of Isoproterenol

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Neuroregulation of Autonomic, Endocrine and Immune Systems

Part of the book series: Topics in the Neurosciences ((TNSC,volume 2))

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Abstract

The moment-to-moment regulation of cardiac output makes the cardiovascular network a dynamic system. In seconds, performance may be altered radically to increase heart rate and stroke volume to meet the needs of the peripheral, metabolizing tissues. Although the magnitude of contractility may be controlled by fiber length, sympathetic stimulation can enhance inotropic state at any given level of end-diastolic volume or pressure. These regulatory mechanisms perform elegantly in the normal heart, but they are substantially impaired in the failing organ.

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References

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Author information

Authors and Affiliations

  1. Lilly Research Laboratories, Departments of Cardiovascular, Eli Lilly And Company, Indianapolis, In, 46285, USA

    J. Scott Hayes & G. Donald Pollock

  2. Pharmacology and Central Nervous System Research, Eli Lilly And Company, Indianapolis, In, 46285, USA

    Ray W. Fuller

Authors
  1. J. Scott Hayes
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  2. G. Donald Pollock
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  3. Ray W. Fuller
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Editor information

Editors and Affiliations

  1. Monsanto Company, St. Louis, Missouri, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  2. Central Nervous System Research Searle Research and Development, G. D. Searle & Co., Skokie, Illinois, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Hugh C. Hendrie M. B. Ch.B. (Chairman and Albert E. Sterne Professor of Psychiatry) (Chairman and Albert E. Sterne Professor of Psychiatry)

  4. Section of Applied and Theoretical Neurobiology The Institute of Psychiatric Research and Departments of Psychiatry and Biochemistry, Indiana University School of Medicine Indiana University Medical Center, Indianapolis, Indiana, USA, 46223

    Joseph N. Hingtgen Ph.D. (Professor of Psychology and Neurobiology) (Professor of Psychology and Neurobiology)

  5. Departments of Pharmacology & Toxicology & Psgchiatry Program in Medical Neurobiologg, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Morris H. Aprison Ph.D. (Distinguished Professor of Neurobiology and Biochemistry) (Distinguished Professor of Neurobiology and Biochemistry)

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© 1986 Matinus Nijhoff Publishing, Boston

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Hayes, J.S., Pollock, G.D., Fuller, R.W. (1986). In Vivo Cardiovascular Responses to Isoproterenol, Dopamine, and Tyramine Following Prolonged Infusion of Isoproterenol. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_26

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  • DOI: https://doi.org/10.1007/978-1-4613-2315-0_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9424-5

  • Online ISBN: 978-1-4613-2315-0

  • eBook Packages: Springer Book Archive

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