Skip to main content
SpringerLink
Log in

Glutamate, Gaba and Cholinergic Systems in the NTS, DMN and Hypoglossal Nucleus of the Rat *

  • Chapter
Neuroregulation of Autonomic, Endocrine and Immune Systems

Part of the book series: Topics in the Neurosciences ((TNSC,volume 2))

  • 117 Accesses

Abstract

Several nuclei within the medulla oblongata are involved in processing afferent inputs from several peripheral organs as well as from higher centers within the central nervous system. Thus, the nucleus of the solitary tract (NTS) has been shown to receive inputs from respiratory [1], gastrointestinal [2], gustatory [3,4], and baroreceptor [5-9] systems, as well as from central areas including the hypothalamus [10,11], and the medial lateral frontal cortex [12,13]. Data have been published to show that the dorsal motor nucleus of the vagus (DMN) receives afferent inputs from the paraventricular nucleus of the hypothalamus, nucleus reticularis gigantocellularis and the NTS [14] while the hypoglossal nucleus (n.XII) receives inputs from the reticular formation, the spinal V complex and the NTS [15].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. von Euler, C, J.N. Hayward, I. Martilla, and R.J. Wyman. Respiratory neurons of the ventrolateral nucleus of the solitary tract of the cat: Vagal input, spinal connections and morphological identification. Brain Res., 61 (1973) 1–22.

    Article  Google Scholar 

  2. Gwyn, D.G., R.A. Leslie, and D.A. Hopkins. Gastric afferents to the nucleus of the solitary tract in the cat. Neurosci. Lett., 14 (1979) 13–17.

    Article  PubMed  CAS  Google Scholar 

  3. Bloomquist, A.J. and A. Antem. Localization of the terminals of the tongue afferents in nucleus of the solitary tract. J. Comp. Neurol. 124 (1965) 127–130.

    Article  Google Scholar 

  4. Ogawa, H., T. Imoto, and T. Hayama. Taste relay neurons in the solitary nucleus of rats. Neurosci. Lett., 18 (1980) 295–299.

    Article  PubMed  CAS  Google Scholar 

  5. Berger, A.J. Distribution of carotid sinus nerve afferent fibers to solitari tract nuclei of the cat using transganglionic transport of horseradish peroxidase. Neurosci. Lett., 14 (1979) 153–158.

    Article  PubMed  CAS  Google Scholar 

  6. Crill, W.E. and D.J. Reis. The distribution of carotid sinus and depressor nerves in cat brainstem. Am. J. Physiol., 214 (1968) 269–270.

    PubMed  CAS  Google Scholar 

  7. Kalia, M. and R.V. Welles. Brain stem projections of the aortic nerve in the cat: A study using tetramethyl benzidine as the substrate for horseradish peroxidase. Brain Res., 188 (1980) 232–2.

    Article  Google Scholar 

  8. Miura, M. and D.J. Reis. The role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro- and chemoreceptors. Am. J. Physiol, 223 (1972) 525–548.

    CAS  Google Scholar 

  9. Seller, H. and M. Illert. The localization of the first synapse in the carotid sinus baroreceptor reflex pathway and its alteration of the afferent input. Pflugers Arch., 306 (1969) 1–19.

    Article  PubMed  CAS  Google Scholar 

  10. Nilaver, G., E.A. Zimmerman, J. Wilkins, J. Michaeles, D. Hoffman, and A.J. Silverman. Magnocellular hypothalamic projections to the lower brain stem and spinal cord of the rat. Immunocytochemical evidence for the predominance of oxytocin-neurophysin system compared to the vasopressin-neurophysin system. Neuroendocrinology, 30 (1980) 150–158.

    Article  PubMed  CAS  Google Scholar 

  11. Saper, C.B., A.D. Loewy, L.W. Swanson, and W.M. Cowan. Direct hypothalamo-autonomic connections. Brain Res., 117 (1976) 305–312.

    Article  PubMed  CAS  Google Scholar 

  12. Terreberry, R.R. and E.J. Neafsey. Rat medial frontal cortex: A visceral motor region with a direct projection to the solitary nucleus. Brain Res., 278 (1983) 245–249.

    Article  PubMed  CAS  Google Scholar 

  13. Van Der Kooy, D., L.Y. Koda, J.F. McGinty, C.R. Gerfen, and F.E. Bloom. The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J. Comp. Neurol. 224 (1984) 1–24.

    Article  PubMed  Google Scholar 

  14. Rogers, R.C., H. Kita, L. Butcher, and D. Dovin. Afferent projections to the dorsal motor nucleus of the vagus. Brain Res. Bull., 15 (1980) 365–373.

    Article  Google Scholar 

  15. Borke, R.C., M.E. Nau, and R.L. Ringler, Jr. Brain stem afferents of hypoglossal neurons in the rat. Brain Res. 269 (1983) 47–55.

    Article  PubMed  CAS  Google Scholar 

  16. Hodes, 2.1., M.A. Rea, D.L. Felten, and M.H. Aprison. Specific binding of the muscarinic antagonist 3H-quinuclidinyl benzilate is not associated with preganglionic motor neurons in the dorsal motor nucleus of the vagus. Neurochem. Res., 8 (1983) 73–87.

    Article  PubMed  CAS  Google Scholar 

  17. Siemers, E.R., M.A. Rea, D.L. Felten, and M.H. Aprison. Distribution and uptake of glycine, glutamate and γ-amino-butyric acid in the vagal nuclei and eight other regions of the rat medulla oblongata. Neurochem. Res., 7 (1982) 455–468.

    Article  PubMed  CAS  Google Scholar 

  18. Simon, J.R., B. Oderfeld-Nowak, D.L. Felten, and M.H. Aprison. Distribution of choline acetyltransferase, muscarinic receptor binding and choline uptake in discrete areas of the rat medulla oblongata. Neurochem. Res., 6 (1981) 497–505.

    Article  PubMed  CAS  Google Scholar 

  19. Nieoullon, A. and N. Dusticier. Glutamate decarboxylase distribution in discrete motor nuclei in the cat brain. J. Neurochem. 37 (1981) 202–209.

    Article  PubMed  CAS  Google Scholar 

  20. Reis, D.J., M.H. Perrone, and W.T. Talman. Glutamic acid as the neurotransmitter of baroreceptor afferents in the nucleus tractus solitarii: Possible relationship to neurogenic hypertension. In J.P. Buckley and CM. Ferrario (Eds.), Central Nervous System Mechanisms in Hypertension, Raven Press, NY, 1981, pp. 37–48.

    Google Scholar 

  21. Bousquet, P., J. Feldman, R. Block, and J. Schwartz. Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS. Naunyn-Schmiedeberg’s Arch. Pharmacol. 319 (1982) 168–172.

    Article  CAS  Google Scholar 

  22. Storm-Mathisen, J. High affinity uptake of GABA in presumed GABAergic nerve endings in rat brain. Brain Res., 84 (1975) 409–427.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN, 46223, USA

    J. R. Simon, S. K. DiMicco & M. H. Aprison

Authors
  1. J. R. Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. K. DiMicco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. H. Aprison
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Monsanto Company, St. Louis, Missouri, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  2. Central Nervous System Research Searle Research and Development, G. D. Searle & Co., Skokie, Illinois, USA

    Robert C. A. Frederickson Ph.D. (Senior Director) (Senior Director)

  3. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Hugh C. Hendrie M. B. Ch.B. (Chairman and Albert E. Sterne Professor of Psychiatry) (Chairman and Albert E. Sterne Professor of Psychiatry)

  4. Section of Applied and Theoretical Neurobiology The Institute of Psychiatric Research and Departments of Psychiatry and Biochemistry, Indiana University School of Medicine Indiana University Medical Center, Indianapolis, Indiana, USA, 46223

    Joseph N. Hingtgen Ph.D. (Professor of Psychology and Neurobiology) (Professor of Psychology and Neurobiology)

  5. Departments of Pharmacology & Toxicology & Psgchiatry Program in Medical Neurobiologg, Indiana University School of Medicine, Indianapolis, Indiana, USA, 46223

    Morris H. Aprison Ph.D. (Distinguished Professor of Neurobiology and Biochemistry) (Distinguished Professor of Neurobiology and Biochemistry)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Matinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Simon, J.R., DiMicco, S.K., Aprison, M.H. (1986). Glutamate, Gaba and Cholinergic Systems in the NTS, DMN and Hypoglossal Nucleus of the Rat *. In: Frederickson, R.C.A., Hendrie, H.C., Hingtgen, J.N., Aprison, M.H. (eds) Neuroregulation of Autonomic, Endocrine and Immune Systems. Topics in the Neurosciences, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2315-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2315-0_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9424-5

  • Online ISBN: 978-1-4613-2315-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation