Skip to main content

Drug Kinetics and Continuous Arteriovenous Hemofiltration

  • Chapter
Acute Continuous Renal Replacement Therapy

Part of the book series: Developments in Nephrology ((DINE,volume 13))

  • 61 Accesses

Abstract

Since Kramer’s initial description of the procedure he called continuous arteriovenous hemofiltration (CAVH) (1), its role in the management of acute renal failure has been considerably expanded (2–4). Because most patients undergoing CAVH are critically ill, optimal management of concurrent medications is a necessity. Only recently has drug handling during CAVH been studied in any detail (4–8). It is the purpose of this chapter to review the factors related to drug handling during CAVH, to establish uniform terminology and methodology for drug data collection, to summarize the available data concerning specific drugs, and to recommend an approach to drug administration in patients undergoing CAVH.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kramer P, Wigger W. Rieger J, et al: Arteriovenous hemofiltration: a new and simple method for treatment of overhydrated patients resistant to diuretics. Klin Wochenschr 55:1121–2, 1977.

    Article  PubMed  CAS  Google Scholar 

  2. Golper TA: Continuous arteriovenous hemofiltration in acute renal failure. Am J Kid Dis 1985 (In press).

    Google Scholar 

  3. Kaplan AA, Longnecker RE, Folkert VW: Continuous arteriovenous hemofiltration. Ann Intern Med 100:358–367, 1984.

    PubMed  CAS  Google Scholar 

  4. Paganini EP, O’Hara P, Nakamoto S: Slow continuous Ultrafiltration in hemodialysis resistant oliguric acute renal failure patients. Trans Am Soc Artif Intern Organs 30:173–177, 1984.

    PubMed  CAS  Google Scholar 

  5. Kaplan AA, Longnecker RE, Folkert VW: Continuous hemofiltration: in response (Letters). Ann Intern Med 101:145–146, 1984.

    Google Scholar 

  6. Ossenkopple GJ, Van der Muellen J, Bronsveld W, et al: Continuous arteriovenous hemofiltration as an adjunctive therapy for septic shock. Crit Care Med 13:102–104, 1985.

    Article  Google Scholar 

  7. Golper TA, Pulliam J, Bennett WM: Removal of therapeutic drugs by continuous arteriovenous hemofiltration. Arch Intern Med 145:1651–1652, 1985.

    Article  PubMed  CAS  Google Scholar 

  8. Golper TA, Wedel SK, Kaplan AA, Saad A-M, Donta ST, Paganini EP: Drug removal during continuous arteriovenous hemofiltration: theory and clinical observations. Intern J Artif Organs 1985 (In press).

    Google Scholar 

  9. Colton CK, Henderson LW, Ford CA, et al: Kinetics of hemodiafiltration. I. In vitro transport characteristics of a hollow fiber blood ultrafilter. J Lab Clin Med 85:355–371, 1975.

    PubMed  CAS  Google Scholar 

  10. Leypoldt JK, Frigon RP, Henderson LW: Dextran sieving coefficients of hemofilter membranes. Trans Am Soc Artif Intern Organs 29:678–683, 1983.

    PubMed  CAS  Google Scholar 

  11. Frigon RP, Leypoldt JK, Alford MF, et al: Hemofilter solute sieving is not governed by dynamically polarized protein. Ibid. 486–490, 1984.

    Google Scholar 

  12. Golper TA, Saad A-M: Gentamicin and phenytoin in vitro sieving characteristics through polysulfone hemofilters: effect of flow rate, drug concentration, and solvent hemofilters: effect of flow rate, drug concentration, and solvent systems (submitted for review).

    Google Scholar 

  13. Reidenberg MM, Affrime M: Influence of disease on binding of drugs to plasma protein. Ann NY Acad Sci 226:115–126, 1973.

    Article  PubMed  CAS  Google Scholar 

  14. Dayton PG, Israili ZH, Perel JM: Influence of binding on drug metabolism and distribution. Ibid. 226:172–194, 1973.

    CAS  Google Scholar 

  15. Anton AH: Increasing activity of sulfonamides with displacing agents. Ibid. 226:273–292, 1973.

    CAS  Google Scholar 

  16. Reidenberg MM: The binding of drugs to plasma protein and the interpretation of measurements of plasma concentration of drugs in patients with poor renal function. Am J Med 62:460–470, 1977.

    Google Scholar 

  17. Tillement JP, Lhoste F, Fiudicelli TF: Diseases and drug protein binding. Clin Pharmacokin 3:144–154, 1978.

    Article  CAS  Google Scholar 

  18. McNamara PJ, Lalka D, Gibaldi M: Endogenous accumulation products and serum protein binding in uremia. J Lab Clin Med 98:740, 1981.

    Google Scholar 

  19. Gulyassy PF, Depner TA: Impaired binding of drugs and endogenous ligands in renal disease. Am J Kid Dis 2:578–601, 1983.

    PubMed  CAS  Google Scholar 

  20. Keller F, Wilms H, Schulte G, et al: Effect of plasma protein binding, volume of distribution and molecular weight on the fraction of drugs eliminated by hemodi-alysis. Clin Nephrol 19:201–205, 1983.

    PubMed  CAS  Google Scholar 

  21. Suh B, Craig WA, England AC, et al: Effect of the free fatty acids on protein binding of antimicrobial agents. J Infect Dis 143:609–616.

    Google Scholar 

  22. Kraft D, Lode H: Elimination of ampicillin and genta-micin by hemofiltration. Klin Wochenschr 57:195–196, 1979.

    Article  PubMed  Google Scholar 

  23. Klein E, Holland FF, Eberle K: Rejection of solutes by hemofiltration membranes. ASAIO J 1:15–23, 1978.

    Google Scholar 

  24. Rockel A, Gilge U, Liewald A, et al: Elimination of low molecular weight proteins during hemofiltration. Artif Organs 6:307–311, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Michaels AS: Analysis and prediction of sieving curves for ultrafiltration membranes: a universal correlation? Separation Sci and Tech 15:1305–1322, 1980.

    Article  CAS  Google Scholar 

  26. Feldhoff P, Tunham T, Klein E: Effect of plasma proteins on the sieving spectra of hemofilters. Artif Organs 8:186–192, 1984.

    Article  PubMed  CAS  Google Scholar 

  27. Jaffrin MY, Vantard G, Granger A: A concentration polarization model of hemofiltration with highly permeable membranes. ASAIO J 2:73–85, 1985.

    Google Scholar 

  28. Dodd NJ, O’Donovan RM, Bennett-Jones DN: Arteriovenous haemofiltration: a recent advance in the management of renal failure. Br Med J 287:1008–1010, 1983.

    Article  CAS  Google Scholar 

  29. Pauls A, Grigoleit H-G, Von Herrath D, Schaefer K: Comparison of drug elimination by current methods of blood purification. Blood Purification 2:14–22, 1984.

    Article  CAS  Google Scholar 

  30. Zarowitz BJM, Anandan JV, Jayashankar J, et al: Ultra-filtration clearance of aminoglycoside antibiotics. Drug Intell Clin Pharm 19:459, 1985.

    Google Scholar 

  31. Lauer A, Saccaggi A, Ronco C, et al: Continuous arteriovenous hemofiltration in the critically ill patient. Ann Intern Med 99:455–460, 1983.

    PubMed  CAS  Google Scholar 

  32. Bennett WM, Aronoff GR, Morrison G, et al: Drug prescribing in renal failure: dosing guidelines for adults. Am J Kid Dis 3:155–193, 1983.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishing

About this chapter

Cite this chapter

Golper, T. (1986). Drug Kinetics and Continuous Arteriovenous Hemofiltration. In: Paganini, E.P. (eds) Acute Continuous Renal Replacement Therapy. Developments in Nephrology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2311-2_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2311-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9422-1

  • Online ISBN: 978-1-4613-2311-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics