Abstract
Estrogens promote the development of breast cancer and stimulate the growth in vitro of some breast cancer cell lines (1) (2), but the mechanism of their cancerogenic and mitogenic action is unknown. We have used the hormone-responsive MCF7 breast cancer cell line to analyse the mechanism by which estrogens regulate both the biosynthesis of specific proteins and cell proliferation. Estrogen-regulated proteins have been detected by a number of approaches in several metastatic breast cancer cell lines, mostly MCF7 cells. These proteins are generally of unknown function (except for the progesterone receptor (RP)) and defined according to their molecular weight under denaturating conditions by SDS-gel polyacrylamide gel electrophoresis, e.g. 52 K (3), 28 K (4). More recently, an estrogen-regulated mRNA (pS2) coding for a secreted protein has also been described (5).
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© 1986 Martinus Nijhoff Publishing, Boston
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Rochefort, H. et al. (1986). Estrogen-Regulated Proteins and Autocrine Control of Cell Growth in Breast Cancer. In: Rich, M.A., Hager, J.C., Taylor-Papadimitriou, J. (eds) Breast Cancer: Origins, Detection, and Treatment. Developments in Oncology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2309-9_5
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DOI: https://doi.org/10.1007/978-1-4613-2309-9_5
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