Advertisement

Of Mice and Women: Genetic Analysis of Breast Cancer In Families

  • Mary Claire King
Part of the Developments in Oncology book series (DION, volume 43)

Abstract

Breast cancer is genetic, in the sense that breast tumor development is initiated by alterations—mutations, somatic recombinations, duplications, and so on—of DNA sequences in breast epithelial cells. These alterations may be inherited in the germ line, or may be due to somatic events induced by environmental mutagens. If an alteration is inherited in the germ line in a family, then an unusually large number of breast cancer cases are likely to appear in that family. If inherited alterations are common, then breast cancer will tend to cluster in families.

Keywords

Breast Cancer Mouse Mammary Tumor Virus Breast Cancer Susceptibility Male Breast Cancer Mammary Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. King MC, Lee GT, Spinner NR, Thomson G, Wrensch MR. 1984. AnnRevPubHlth 5:1–52.CrossRefGoogle Scholar
  2. 2.
    Schwartz AG, King MC, Belle SH, Satariano WA, Swanson GM. 1985. JNatCancerInst (in press).Google Scholar
  3. 3.
    King MC, Elston RC. 1985. GenetEpid2 (In press).Google Scholar
  4. 4.
    Weinberg RA. 1983. ScientificAmerican 247:126–142.CrossRefGoogle Scholar
  5. 5.
    Cooper GM. 1982. Science 217:801–806.PubMedCrossRefGoogle Scholar
  6. 6.
    Santos E. Martin-Zanca D, Reddy EP, Pierotti MA, Delia Porta G, Barbacid M. 1984. Science 223:661–664.PubMedCrossRefGoogle Scholar
  7. 7.
    Feig LA, Bast RC, Knapp RC, Cooper GM. 1984. Science 223:698–701.PubMedCrossRefGoogle Scholar
  8. 8.
    Sukumar S, Notario V, Martin-Zanca D, Barbacid M. 1983. Nature 306:658–661.PubMedCrossRefGoogle Scholar
  9. 9.
    Kozbar D, Croce CM. 1984. Cancer Res 44:438–441.Google Scholar
  10. 10.
    Harris LF, Bates HA, Miller LL, Crutchfield CE, Henderson BA, Hickok DF. 1985. IntAssocBreastCancerResProceedings, p.74Google Scholar
  11. 11.
    Day NK, Witkin SS, Sarkar NH, Kinne D, Jussawalla DJ, Levin A, Hsia CC,ler N, Good RA. 1981. ProcNatlAcadSciUSA 78:2483–2487.PubMedCrossRefGoogle Scholar
  12. 12.
    Nusse R, Varmus HE. 1982. Cell 31:99–109.PubMedCrossRefGoogle Scholar
  13. 13.
    Peters G, Brookes S, Smith R, Dickson C. 1983. Cell 33:369–377.PubMedCrossRefGoogle Scholar
  14. 14.
    Casey G, Smith R, Brookes S, McGillivray D, Dickson C, Peters G. 1985. IntAssocBreastCancer ResProceedings, p. 173.Google Scholar
  15. 15.
    Sonnenberg A, Nuse R, Hilgers J. 1985. Int Assoc Breast Cancer Res Proceedings, p. 114.Google Scholar
  16. 16.
    Callahan R, Drohan W, Tronick S, Schlom J. 1982. ProcNatlAcadSciUSA 79:5503–5507.PubMedCrossRefGoogle Scholar
  17. 17.
    Callahan R, Ali I, Bassin R, Horn T, Mariani-Costantini R, Robbins J, Schlom J. 1985. IntAssocBreastCancerResProceedings, p. 36.Google Scholar
  18. 18.
    Go RCP, King MC, Bailey-Wilson J, Elston RC, Lynch HT. 1983. JNatCancerInst 71:455–461.PubMedGoogle Scholar
  19. 19.
    White R, Leppart M, Bishop DT, Barker D, Berkowitz J, Brown C, Callahan P, Holm T, Jerominski L. 1985. Nature 313: 101: 101–105.CrossRefGoogle Scholar
  20. 20.
    Land MA, Parada LF, Weinberg RA. 1983. Science 222:771–778.PubMedCrossRefGoogle Scholar
  21. 21.
    Feder J, Yen L, Wijsman E, Wang L, Wilkins L, Schroder J, Spurr N, Cann H, Blumenberg M, Cavalli-Sforza L. 1985 AmerJHumGenet. In press.Google Scholar
  22. 22.
    Cavanee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie Bl, Murphree AL, Strong LC, White Rl. 1983. Nature 305:779–784.CrossRefGoogle Scholar
  23. 23.
    Cavanee WK, Hansen MF, Nordenskjold M, Kock E, Maumenee I, Squire JA, Phillips RA, Gallie BL. 1985. Science 228:501–503.CrossRefGoogle Scholar
  24. 24.
    Human Gene Mapping 7. 1984. CytogenetCellGenet 37:Nos. 1–4.Google Scholar
  25. 25.
    Lange K, Boehnke M. 1982. AmerJHumGenet 34:842–845.PubMedGoogle Scholar
  26. 26.
    Ewens WJ, Spielman RS, Harris H, 1981. Genetics 78:3748–3750.Google Scholar
  27. 27.
    Kan YW, Dozy AM. 1978. Lancet 2 (8096):910–912.PubMedGoogle Scholar
  28. 28.
    Chang JC, Kan YW. 1981. Lancet 2:1127–129.PubMedCrossRefGoogle Scholar
  29. 29.
    Gusella JF, Wexler NS, Conneally PM, et al. 1983. Nature 306:234–238.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • Mary Claire King
    • 1
  1. 1.School of Public HealthUniversity of CaliforniaBerkeleyUSA

Personalised recommendations