Of Mice and Women: Genetic Analysis of Breast Cancer In Families

  • Mary Claire King
Part of the Developments in Oncology book series (DION, volume 43)


Breast cancer is genetic, in the sense that breast tumor development is initiated by alterations—mutations, somatic recombinations, duplications, and so on—of DNA sequences in breast epithelial cells. These alterations may be inherited in the germ line, or may be due to somatic events induced by environmental mutagens. If an alteration is inherited in the germ line in a family, then an unusually large number of breast cancer cases are likely to appear in that family. If inherited alterations are common, then breast cancer will tend to cluster in families.


Breast Cancer Mouse Mammary Tumor Virus Breast Cancer Susceptibility Male Breast Cancer Mammary Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • Mary Claire King
    • 1
  1. 1.School of Public HealthUniversity of CaliforniaBerkeleyUSA

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