Abstract
Verapamil is a synthetic papaverine derivative from the group of Ca2+ channel blockers. Its main therapeutic use is in the treatment of angina pectoris and atrial and supraventricular tachy/arrhythmias (1). On the cellular level, it is mainly known for its inhibitory effect on the slow Ca2+ channel (2) but it has also been shown to affect other ion fluxes (3,4) and ion flux dependent processes in many systems (5,6,7,8). In order to study the mechanism of action of verapamil at the molecular level, we used synaptic plasma membrane (SPM) vesicles derived from osmotically shocked rat brain synaptosomes (9). As also in other membrane vesicles, ionic gradients across the SPK can be easily created by choice and used to drive transport processes of specific carriers.
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© 1986 Martinus Nijhoff Publishing, Boston
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Erdreich, A., Rahamimoff, H. (1986). Studies on the Mechanism of the Inhibitory Action of Verapamil on Ca2+ Transport. In: Rahamimoff, R., Katz, B. (eds) Calcium, Neuronal Function and Transmitter Release. Topics in the Neurosciences, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2307-5_37
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DOI: https://doi.org/10.1007/978-1-4613-2307-5_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9420-7
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