On the Voltage Dependence of Neurotransmitter Release

  • H. Parnas
  • I. Parnas
  • J. Dudel
Part of the Topics in the Neurosciences book series (TNSC, volume 1)


The process of nerve evoked transmitter release requires Ca++ in the extracellular medium (1,2). The specific link for release is the increase in inracellular Ca++ concentration (3,4) resulting from terminal depolarization and inflow of calcium. Indeed, this is considered the only role of membrane depolarization; no additional effects are presumed in any of the processes that follow the entry of calcium ions and lead to the fusion of synaptic vesicles with the terminal membrane, exocytosis and release. If it is accepted that Ca++ ions are the only trigger for release, it follows that initiation of release results from an increase in intracellular Ca++ concentrations near critical sites. Correspondingly, termination of release must result from a drop in Ca++ concentration near these critical sites to levels insufficient to support release (5,6,7).


Release Site Transmitter Release Test Pulse Quantal Content Synaptic Delay 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • H. Parnas
    • 1
  • I. Parnas
    • 1
  • J. Dudel
    • 2
  1. 1.Dept. Neurobiology, Institute of Life SciencesHebrew University of JerusalemMunichGermany
  2. 2.Institute of PhysiologyTechnical UniversityMunichGermany

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