Karyotypic Progression and Metastasis Formation of Human Tumors

  • Peter C. Nowell
  • Gloria Balaban
Part of the Developments in Oncology book series (DION, volume 41)


In recent years, chromosome studies have contributed significantly to our understanding of fundamental tumor biology in a number or areas. Based on the work from many laboratories, four general statements can be made about karyotypic alterations in neoplasia: 1) most tumors have chromosome abnormalities, which are not present in other cells of the body, 2) in a given tumor, all the neoplastic cells often have the same cytogenetic change, or related changes, 3) although chromosome alterations often differ between tumors, there are nonrandom patterns, and 4) chromosome abnormalities are more extensive in advanced tumors.


Chromosome Abnormality Cytogenetic Data Cytogenetic Change Karyotypic Change Vertical Growth Phase 
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  1. 1.
    Nowell, P. Science 194: 23–28, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Fialkow, P. Ann. Rev. Med. 30: 135–143, 1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Rowley, J.D. and Testa, J.R. Adv. Cancer Res. 36: 103,148, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Yunis, J.J. Science 221: 227–236, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    Klein, G. Nature 294: 313–318, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Nowell, P.C., Emanuel, B.S., Finan, J.B., Erikson, J. and Croce, C.M. Microbiological Sciences 1: 223–228, 1984.PubMedGoogle Scholar
  7. 7.
    Brodeur, G.M., Seeger, R., Schwab, M., Varmus, H.E. and Bishop, J.M. Science 224: 1121–1124, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    Koprowski, H., Herlyn, M., Balaban, G., Parmiter, A., Ross, A. and Nowell, P.C. Somat. Cell Molec. Genet. 1985, in press.Google Scholar
  9. 9.
    Nowell, P. In: Chromosome Mutation and Neoplasia (ed. J. German), Alan R. Liss, New York, 1983, pp. 413–432.Google Scholar
  10. 10.
    Cifone, M.A. and Fidler, I.J. Proc. Natl. Acad. Sci. USA 78: 6949–6952, 1981.PubMedCrossRefGoogle Scholar
  11. 11.
    Mark, J. Eur. J. Cancer 5: 307, 1969.Google Scholar
  12. 12.
    Levan, G. and Mitelman, F. Hereditas 84: 1, 1976.PubMedCrossRefGoogle Scholar
  13. 13.
    Balaban, G., Herlyn, M., Guerry, D., Bartolo, R., Koprowski, H., Clark, W. and Nowell, P.C. Cancer Genet. Cytogenet. 11: 429, 1983.CrossRefGoogle Scholar
  14. 14.
    Herlyn, M., Balaban, G., Bennicelli, J., Guerry, D., Halaban, R., Herlyn, D., Elder, D., Maul, G., Steplewski, Z., Nowell, P., Clark, W. and Koprowski, H. J. Natl. Cancer Inst. 1985, in press.Google Scholar
  15. 15.
    Balaban, G., Herlyn, M., Guerry, D., Parmiter, A., Nowell, P. and Clark, W. Jr. Proc. Amer. Assoc. Cancer Res. 1985, in press.Google Scholar
  16. 16.
    Clark, W. Jr., Elder, D., Guerry, D., Epstein, M., Greene, M. and Van Horn, M. Hum. Pathol. 15: 1147–1165, 1984.PubMedCrossRefGoogle Scholar
  17. 17.
    Quinn, L.A., Woods, L.K., Merrick, S.B., Arabasz, N.M., Moore, G.E. J. Natl. Cancer Inst. 59: 301–307, 1977.Google Scholar
  18. 18.
    Feder, M. and Gilbert, F. J. Natl. Cancer Inst. 70: 1051–1056, 1983.PubMedGoogle Scholar
  19. 19.
    Feder, M.M. Thesis, Department of Human Genetics, University of Pennsylvania, 1983.Google Scholar
  20. 20.
    Reynolds, C.P., Biedler, J.L., Spengler, B.A., Ross, R.A., Reynolds, D.A., Smith, R.G. and Frenkel, E.P. Proc. Am. Assoc. Cancer Res. 23: 11, 1983.Google Scholar
  21. 21.
    Kusyk, C.J., Seski, J.C., Medlin, W.V. and Edwards, C.L. J. Natl. Cancer Inst. 66: 1021–1025, 1981.PubMedGoogle Scholar
  22. 22.
    Kusyk, C.J., Turpening, E.L., Edwards, C.L., Wharton, J.T. and Copeland, L.J. Gynecologic Oncol. 14: 324–338, 1982.CrossRefGoogle Scholar
  23. 23.
    Hagemeister, A., Hoehn, W. and Smit E.M.E. Cancer Res. 39: 4662–4667, 1979.Google Scholar
  24. 24.
    Reichmann, A., Martin, P. and Levin, B. Int. J. Cancer 28: 431–440, 1981.PubMedCrossRefGoogle Scholar
  25. 25.
    Wang, N., Trend, B., Bronson, D.L. and Fraley, E.E. Cancer Res. 40: 796–802, 1980.PubMedGoogle Scholar
  26. 26.
    Lin, C.R., Chen, W.S., Kruiger, W., Stolarsky, L.S., Weber, W., Evans, R.M., Verma, I.M., Gill, G.N. and Rosenfeld, M.G. Science 224: 843–848, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1986

Authors and Affiliations

  • Peter C. Nowell
    • 1
  • Gloria Balaban
    • 1
    • 2
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Human GeneticsUniversity of Pennsylvania School of MedicineUSA

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