An autoradiographic approach for studying the distribution of neurotransmitter receptor binding sites on biopsy samples of human gliomas

  • D. E. Bateman
  • J. M. Candy
  • R. H. Perry
  • J. A. Edwardson


A technique for the autoradiographic localisation of neurotransmitter binding sites on human gliomas in biopsy samples is described. Using this approach it is possible to correlate the distribution of neurotransmit-ter binding sites with histological findings on the same tissue section. The distribution of nicotinamide adenine dinucleotide, cholinergic muscarinic and noradrenergic β-receptors in astrocytoma biopsy samples are reported and their distribution compared with the histological appearance of the biopsy section.

Key words

human gliomas autoradiography receptors neurotransmitters 


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Copyright information

© Martinas Nijhoff Publishers, Boston 1986

Authors and Affiliations

  • D. E. Bateman
    • 1
    • 2
  • J. M. Candy
    • 1
  • R. H. Perry
    • 1
  • J. A. Edwardson
    • 1
  1. 1.MRC Neuroendocrinology UnitNewcastle General HospitalNewcastle upon TyneUK
  2. 2.Wessex Neurological CentreSouthampton General HospitalSouth-amptonUK

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