The Effect of Selected Antibiotics on the Endogenous Intestinal Microflora and its Consequences for Experimental Tumor Growth in BALB/C Mice

  • K. Roszkowski
  • H. L. Ko
  • D. van der Waaij
  • W. Roszkowski
  • J. Jeljaszewicz
  • G. Pulverer
Part of the University of South Florida International Biomedical Symposia Series book series (EMISS, volume 18)

Abstract

In previous studies we have shown that some antibiotics may influence the growth of experimental tumors. Concerning rifampicin an enhancing effect on the tumor development was combined with the impairment of some parameters of antitumor immunity (6). A marked suppression of the antitumor immunity was also observed in mezlocillin treated mice (5). However, this antibiotic caused a surprising antitumor effect when given during early tumor growth. Because a direct cytotoxic activity of mezlocillin could not be demonstrated, indirect mechanisms have been suggested for this mezlocillin effect. The present paper deals with the influence of mezlocillin and other selected antibiotics on the endogenous intestinal flora of BALB/c mice and on the local growth of sarcoma L-1 tumor.

Keywords

Sarcoma Gentamicin Rifampicin Cefotaxime Clindamycin 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • K. Roszkowski
    • 1
  • H. L. Ko
    • 2
  • D. van der Waaij
    • 3
  • W. Roszkowski
    • 1
  • J. Jeljaszewicz
    • 4
  • G. Pulverer
    • 2
  1. 1.Institute of Lung DiseasesWarsawPoland
  2. 2.Institute of HygieneUniversity of CologneWest Germany
  3. 3.University HospitalGroningenThe Netherlands
  4. 4.National Institute of HygieneWarsawPoland

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