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The Role of Post-Endotoxin Serum Components from BCG Infected Mice in the Protection of Compromised Hosts

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Immunobiology and Immunopharmacology of Bacterial Endotoxins

Part of the book series: University of South Florida International Biomedical Symposia Series ((EMISS,volume 18))

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Abstract

The beneficial effects of bacterial toxins have been demonstrated in various experimental models in which the host was compromised by a great variety of different noxae. The induction of nonspecific tolerance by endotoxins to the toxic effects of endotoxins (5) and of nonspecific resistance to infection (9,18) and to lethal X-irradiation (24,36) was of particular interest in our studies. In recent years it has become more apparent that these effects are mediated by humoral factors which are produced and released from lymphoreticular cells after injection of endotoxin. Freedman (13) reported that endotoxin tolerance was passively transferable with serum from tolerant mice. Using a detoxified endotoxin preparation that induced tolerance to the lethal effects of endotoxin after one single pretreatment (42), we were unable to observe this passive transfer effect. The transfer of enhanced resistance to bacterial infection was achieved with post-endotoxin serum from BCG (Mycobacterium bovis Bacille Calmette Guerin) infected mice (30). Moreover, it was reported that such serum (BCG/ET serum) or postendotoxin serum from zymosan treated mice induced protection against the lethal effects of whole-body X-irradiation (1,48).

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Authors and Affiliations

  1. Department of Immunology and Serology, Institute of Hygiene and Medical Microbiology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany

    Renate Urbaschek & Bernhard Urbaschek

  2. German Cancer Research Center Heidelberg, Germany

    Daniela N. Männel

  3. National Institutes of Health, Bethesda, Maryland, USA

    Stephan E. Mergenhagen

Authors
  1. Renate Urbaschek
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  2. Daniela N. Männel
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  3. Stephan E. Mergenhagen
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  4. Bernhard Urbaschek
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Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Andor Szentivanyi (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) & Herman Friedman (Professor and Chairman) (Dean of the College of Medicine Deputy Vice President for Medical Affairs Professor of Pharmacology and Internal Medicine Chairman of the Department of Pharmacology and Therapeutics) &  (Professor and Chairman)

  2. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1986 Plenum Press, New York

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Urbaschek, R., Männel, D.N., Mergenhagen, S.E., Urbaschek, B. (1986). The Role of Post-Endotoxin Serum Components from BCG Infected Mice in the Protection of Compromised Hosts. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_18

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  • DOI: https://doi.org/10.1007/978-1-4613-2253-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9319-4

  • Online ISBN: 978-1-4613-2253-5

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