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Effects of Endotoxin on Mixed Function Oxidase Activity

  • Joseph F. Williams
  • Andor Szentivanyi
Part of the University of South Florida International Biomedical Symposia Series book series (EMISS, volume 18)

Abstract

Over the last several years there has been considerable effort channeled toward development of immunotherapeutic agents. Great strides have been made in the understanding of the immune system, and the elaboration of a multitude of mediators elicited by stimulation of the various cellular components in response to various immunomodulators. However, it is also appreciated that these immunomodulators or the mediators elicited by them may possess activity on cellular systems other than those of the immune network. Understanding these non-immune effects is of major importance for the future clinical application of these agents.

Keywords

Mixed Function Oxidase Heme Oxygenase Activity Hepatic Parenchymal Cell Tolerant Animal Tryptophan Oxygenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    C. O. Abernathy, H. J. Zimmerman, and R. Utili, Effects of endotoxin tolerance on in vivo drug metabolism in mice, Res. Commun. Chem. Path. Pharmacol. 29: 193 (1980).Google Scholar
  2. 2.
    L. J. Berry, Bacterial toxins, CRC Crit. Rev. Toxicol. 5: 238 (1977).CrossRefGoogle Scholar
  3. 3.
    D. M. Bissell and L. E. Hammaker, Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity, Arch. Biochem. Biophys. 176: 91 (1976a).PubMedCrossRefGoogle Scholar
  4. 4.
    D. M. Bissell and L. E. Hammaker, Cytochrome P-450 heme and the regulation of ¿-aminolevulinic acid synthetase in the liver, Arch. Biochem. Biophys. 176: 103 (1976b).PubMedCrossRefGoogle Scholar
  5. 5.
    D. M. Bissell and L. E. Hammaker, Effect of endotoxin on tryptophan pyrrolase and delta-aminolevulinate synthetase: evidence for an endogenous regulatory haem fraction in rat liver, Biochem. 166: 301 (1977).Google Scholar
  6. 6.
    M. D. Burke and S. Orrenius, Isolation and comparison of endoplasmic reticulum membranes and their mixed function oxidase activities from mammalian extrahepatic tissues, Pharmacol. Therap. 7: 549 (1979).CrossRefGoogle Scholar
  7. 7.
    G. Drummond, D. Rosenberg, and A. Kappas, Metal induction of haeme oxygenase without concurrent degradation of cytochrome P-450, Biochem. J. 202: 59 (1982).PubMedGoogle Scholar
  8. 8.
    K. Egawa, M. Yoshida, and N. Kasai, An endotoxin-induced serum factor that depresses hepatic -aminoleuvulinic acid synthetase activity and cytochrome P-450 levels in mice, Microbiol. Immunol. 25: 1091 (1981).PubMedGoogle Scholar
  9. 9.
    J. P. Filkins and B. J. Buchanan, In vivo vs. in vitro effects of endotoxin on glycogenolysis, gluconeogenesis, and glucose utilization, Proc. Soc. Exp. Biol. Med. 155:216 (1977).PubMedGoogle Scholar
  10. 10.
    J. P. Filkins and R. P. Cornell, Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock, Am. J. Physiol. 277: 778 (1974).Google Scholar
  11. 11.
    G. L. Florsheim and J. J. Szeszak, Poly I - Poly C and endotoxins share immunosuppressive properties and increase the toxicity of alpha-amanitin and hexobarbital, Agents Actions 2: 150 (1971).CrossRefGoogle Scholar
  12. 12.
    R. Gasser, H. P. Hauri, and U. A. Meyer, The turnover of cytochrome P-450b, FEBS Lett. 147: 239 (1982).PubMedCrossRefGoogle Scholar
  13. 13.
    R. Gorodischer, J. Krasner, J. J. McDevitt, J. P. Nolan, and S. J. Yaffe, Hepatic microsomal drug metabolism after administration of endotoxin in rats, Biochem. Pharmacol. 25: 351 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    D. W. Nebert and R. M. Friedman, Stimulation of aryl hydrocarbon hydroxylase induction in cell cultures by interferon, J. Virology 11: 193 (1973).PubMedGoogle Scholar
  15. 15.
    J. P. Nolan and M. V. Ali, Endotoxin and the liver. II. Effect of tolerance on carbon tetrachloride-induced injury, J. Med. 4: 28 (1973).PubMedCrossRefGoogle Scholar
  16. 16.
    A. J. Paine, P. Villa, and L. J. Hockin, Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture, Biochem. J. 188: 937 (1980).PubMedGoogle Scholar
  17. 17.
    K. W. Renton and G. J. Mannering, Depression of hepatic cytochrome P-450 dependent monooxygenase systems with administered interferon inducing agents, Biochem. Biophys. Res. Commun. 73: 343 (1976).PubMedCrossRefGoogle Scholar
  18. 18.
    K. W. Renton and T. G. Peterson, Depression of cytochrome F-450-depen- dent drug biotransformation in hepatocytes after the activation of the reticuloendothelial system by dextran sulfate, J. Pharmacol. Exp. Therap. 229: 299 (1984).Google Scholar
  19. 19.
    K. W. Renton, L. B. DeLoria, and G. J. Mannering, Effects of polyribo- inosinic acid polyribocytidylic acid and a mouse interferon preparation on cytochrome P-450-dependent monooxygenase systems in cultures of primary mouse hepatocytes, Mol. Pharmacol. 14: 672 (1978).PubMedGoogle Scholar
  20. 20.
    R. Snyder and H. Remmer, Classes of hepatic microsomal mixed function oxidase inducers, Pharmacol. Therap. 7: 203 (1979).CrossRefGoogle Scholar
  21. 21.
    H. Vainio, Defective drug metabolism in rat liver in endotoxin shock, Ann. Med. Exp. Biol. Fenn. 51: 65 (1973).PubMedGoogle Scholar
  22. 22.
    J. F. Williams and A. Szentivanyi, Effect of Bordetella pertussis vaccine on the drug-metabolizing enzyme system of mouse liver, Fed. Proc. 34: 1001 (1975).Google Scholar
  23. 23.
    J. F. Williams and A. Szentivanyi, Depression of hepatic drug-metabolizing enzyme activity by JL pertussis vaccination, Eur. Pharmacol. 43: 281 (1977).CrossRefGoogle Scholar
  24. 24.
    J. F. Williams and A. Szentivanyi, Possible involvement of alpha-adrenergic mechanisms and reticuloendothelial activation in the effects of bacterial lipopolysaccharide on hepatic enzyme activities, Fed. Proc. 41: 1722 (1982).Google Scholar
  25. 25.
    J. F. Williams and A. Szentivanyi, Investigation of adrenergic and prostaglandin influences in the endotoxin alteration of hepatic heme oxygenase, microsomal mixed-function oxidase, and glucocortiocoid-induced tryptophan oxygenase activities, Immunopharmacol. 6: 75 (1983a).CrossRefGoogle Scholar
  26. 26.
    J. F. Williams and A. Szentivanyi, Effect of endotoxin in endotoxin-tolerant animals on mixed function oxidase and heme oxygenase activities, Pharmacologist 25: 218 (1983b).Google Scholar
  27. 27.
    J. F. Williams and A, Szentivanyi, Induction of tolerance in mice and rats to the effect of endotoxin to decrease the hepatic microsomal mixed-function oxidase system. Evidence for a possible macrophage- derived factor in the endotoxin effect, Int. J. Immunopharmacol. (1985a).Google Scholar
  28. 28.
    J. F. Williams and A. Szentivanyi, Pharmacokinetic and pharmacodynamics parameters affected by RE cell activators, in: “The Reticuloendothelial System: A Comprehensive Treatise,” Vol. VIII: “The Pharmacology of the Reticuloendothelial System,” J. W. Hadden, and A. Szentivanyi, eds., Plenum Publishing, New York (1985b).Google Scholar
  29. 29.
    J. F. Williams, S. Lowitt, and A. Szentivanyi, Depression of hepatic drug-metabolizing activity by Bordetella pertussis, Ann. Allergy 38: 376 (1977).Google Scholar
  30. 30.
    J. F. Williams, S. Lowitt, and A. Szentivanyi, Effect of endotoxin and phenobarbital on heme enzymes of rat liver, Pharmacologist 21: 232 (1979).Google Scholar
  31. 31.
    J. F. Williams, S. Lowitt, and A. Szentivanyi, Involvement of a heat-stable and heat labile component of Bordetella pertussis in the depression of the murine hepatic mixed-function oxidase system, Biochem. Pharmacol. 29: 1483 (1980a).PubMedCrossRefGoogle Scholar
  32. 32.
    J. F. Williams, S. Lowitt, and A. Szentivanyi, Endotoxin depression of shepatic mixed-function oxidase system in C3H/HeJ and C3H/HeN mice, Immunopharmacol. 2: 285 (1980b).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Joseph F. Williams
    • 1
  • Andor Szentivanyi
    • 1
  1. 1.Department of Pharmacology and TherapeuticsUniversity of South Florida College of MedicineTampaUSA

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