Estrogens and Carcinogenicity: An Overview of Information from Studies in Experimental Animal Systems

  • Benita S. Katzenellenbogen
Part of the Reproductive Biology book series (PBTS)

Abstract

It has long been known that sex steroid hormones regulate the growth and differentiation of many normal reproductive tissues. This review will focus on the role of estrogen in several animal tumor systems. Information will be presented on the role of estrogenic hormones in tumor induction as well as their role as regulators of tumor growth and maintenance in a variety of relatively well characterized experimental animal tumor systems. In particular, an attempt is made to relate these effects on tumor induction and tumor maintenance to the general growth stimulatory effects of estrogenic hormones. The systems described include dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in Sprague-Dawley rats, several other experimental mammary tumor systems that differ in their responsiveness to hormones, estrogen induced pituitary tumors in Fischer rats, estrogen induced Leydig cell tumors in Balb/C mice, and estrogen induced renal tumors in hamsters.

Keywords

Estrogen Tamoxifen Progesterone Androgen Estradiol 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Benita S. Katzenellenbogen
    • 1
  1. 1.Department of Physiology, Biophysics and BiochemistryUniversity of IllinoisUrbanaUSA

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