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Fibronectin: Role in Cell Surface Interactions

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Interaction of Cells with Natural and Foreign Surfaces

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Abstract

Since the early 1970’s, interest in fibronectin has increased steadily, and there is now a massive literature on the structure and functional attributes of this complex molecule (see reviews 1–3)o Although its absence or depletion from the surface of transformed cells first brought fibronectin to the attention of those interested in tumour formation and invasion,the fact that it has significant roles to play in the adhesion and migration of normal cells has widened the field to include connective tissue, developmental biology and more recently molecular biology. Fibronectin is now the most studied of all connective tissue components and two major attributes make this glycoprotein of particular interest. Firstly, the glycoprotein has the capacity to bind other connective tissue components and cell surfaces through a series of domains joined by more flexible regions1 (Fig. l). The implication of this is that fibronectin is ideally suited for a role in mediating cell attachment (whether eukaryotic or prokar- yotic) to collagenous extracellular matrices. Secondly, the molecule is widespread in vivo, deposited in connective tissues and basement membranes and present in a soluble form in many body fluids including plasma, cerebrospinal and amniotic fluids.1–3

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Authors and Affiliations

  1. Biosciences Division Unilever Research, Colworth Laboratory, Sharnbrook, Bedford, MK44 1LQ, UK

    John R. Couchman & Anne Woods

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  1. Royal College of Surgeons of England, London, England

    N. Crawford  & D. E. M. Taylor  & 

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© 1986 Plenum Press, New York

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Couchman, J.R., Woods, A. (1986). Fibronectin: Role in Cell Surface Interactions. In: Crawford, N., Taylor, D.E.M. (eds) Interaction of Cells with Natural and Foreign Surfaces. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2229-0_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2229-0_3

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