Evolution of the Subendothelial Growth on Heparinised Aldehyde Crosslinked Arteries
The macromolecular constituents of prostheses of biological origin are recognised by the hydrolytic enzymes of the host and degraded in vivo. The host cells respond to the implantation and biodegradation of vascular substitutes by the synthesis of intraluminal and/or periprosthetic tissues. A neointimai proliferation progressing to an intraluminal occlusion may be one of the reasons of the long term postoperatory failures. Prosthetic aortic allografts in rats were replaced by an endothelialized elastic tissue, patent to blood1,2. The biosynthetic pattern of proteins in the elastin containing scar was similar to that of proteins in the intima-media of host aortal1.
KeywordsHydrolysis Heparin Aldehyde Biodegradation Luminal
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