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Effect of Colchicine on the Acute Phase Serum Amyloid a Protein Response and Splenic Amyloid Deposition During Experimental Murine Inflammation

  • Chapter
Amyloidosis

Abstract

We investigated the effects of colchicine on the acute phase serum amyloid A protein (SAA) response and splenic amyloid A protein (AA) deposition in CBA/J mice undergoing chronic inflammatory stimulation with silver nitrate (AgNO3), and on accelerated amyloid deposition induced by amyloid-enhancing factor (AEF). Colchicine (10 μg daily) significantly lowered splenic AA levels after 25 days of inflammation, as determined by radioimmunoassay. Pretreatment (3 days) with colchicine decreased SAA levels 24 h after AgNO3. It was (unexpectedly) observed that brief pretreatment (12 h) with colchicine augmented the acute phase SAA response to AgNO3 at 24 h. Colchicine stimulated production of both the SAA inducer and lymphocyte-activating factor (LAF) activities of interleukin 1 (IL 1) by macrophages. Decreased SAA levels did not appear to be the mechanism by which colchicine inhibited amyloidosis, since SAA levels fell both in colchicine-treated and control mice after 25 days of inflammation. Colchicine only partially lowered AA deposition after injection of AEF. This effect could be explained by decreased acute phase SAA levels. It is postulated that colchicine inhibits amyloidosis in the pre-deposition period by altering the production of factors (e.g., AEF) required in the deposition phase.

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Author information

Authors and Affiliations

  1. Rheumatic Disease Unit Montreal General Hospital, McGill University, Montreal, Quebec, Canada

    Sydney R. Brandwein

  2. Arthritis Center, Boston University School of Medicine, Boston, Massachusetts, USA

    J. D. Sipe, Martha Skinner & Alan S. Cohen

Authors
  1. Sydney R. Brandwein
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  2. J. D. Sipe
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  3. Martha Skinner
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  4. Alan S. Cohen
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    George G. Glenner

  2. Columbia University, New York, New York, USA

    Elliott F. Osserman

  3. University of Washington, Seattle, Washington, USA

    Earl P. Benditt

  4. State University of New York at Buffalo, Buffalo, New York, USA

    Evan Calkins

  5. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan S. Cohen

  6. New York University School of Medicine, New York, New York, USA

    Dorothea Zucker-Franklin

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© 1986 Plenum Press, New York

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Brandwein, S.R., Sipe, J.D., Skinner, M., Cohen, A.S. (1986). Effect of Colchicine on the Acute Phase Serum Amyloid a Protein Response and Splenic Amyloid Deposition During Experimental Murine Inflammation. In: Glenner, G.G., Osserman, E.F., Benditt, E.P., Calkins, E., Cohen, A.S., Zucker-Franklin, D. (eds) Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2199-6_16

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  • DOI: https://doi.org/10.1007/978-1-4613-2199-6_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9292-0

  • Online ISBN: 978-1-4613-2199-6

  • eBook Packages: Springer Book Archive

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