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Amyloidosis pp 101–108Cite as

Pathogenetic Mechanisms and Precursor Product Relationships in Murine Amyloidosis

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Abstract

Intravenous injection of 125I-labeled isolated mouse serum amyloid P component (SAP) into mice with systemic AA amyloidosis led to specific deposition of the labeled proetin in mayloidotic organs. The amount correlated with the quantity of amyloid present and localized in the same distribution within the organs as the amyloid deposits. Human SAP, when injected intravenously into amyloidotic mice, also localized specifically to the amyloid deposits. These observations establish directly that circulating SAP is the precursor of the amyloid P component (AP) found associated with amyloid deposits. In addition to elucidating one aspect of the pathogenesis of amyloid deposition, these results suggest a means for selective targeting of diagnostic traces and/or effector agents to amyloid deposits in vivo.

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Author information

Authors and Affiliations

  1. MRC Acute Phase Protein Research Group Immunological Medicine Unit Department of Medicine, Royal Postgraduate Medical School, Du Cane Road, London, W12 0HS, UK

    M. L. Baltz, D. Caspi, I. F. Rowe, C. R. K. Hind & M. B. Pepys

  2. Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London, W12 0HS, UK

    D. J. Evans

Authors
  1. M. L. Baltz
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  2. D. Caspi
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  3. I. F. Rowe
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  4. C. R. K. Hind
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  5. D. J. Evans
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  6. M. B. Pepys
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    George G. Glenner

  2. Columbia University, New York, New York, USA

    Elliott F. Osserman

  3. University of Washington, Seattle, Washington, USA

    Earl P. Benditt

  4. State University of New York at Buffalo, Buffalo, New York, USA

    Evan Calkins

  5. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan S. Cohen

  6. New York University School of Medicine, New York, New York, USA

    Dorothea Zucker-Franklin

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© 1986 Plenum Press, New York

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Baltz, M.L., Caspi, D., Rowe, I.F., Hind, C.R.K., Evans, D.J., Pepys, M.B. (1986). Pathogenetic Mechanisms and Precursor Product Relationships in Murine Amyloidosis. In: Glenner, G.G., Osserman, E.F., Benditt, E.P., Calkins, E., Cohen, A.S., Zucker-Franklin, D. (eds) Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2199-6_12

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  • DOI: https://doi.org/10.1007/978-1-4613-2199-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9292-0

  • Online ISBN: 978-1-4613-2199-6

  • eBook Packages: Springer Book Archive

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