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Selective Therapy of Hepatic Cancers Using Microspheres

  • John W. Gyves

Abstract

Regional chemotherapy is based on the premise that many chemotherapeutic agents display a steep dose response for toxicity and for therapeutic effect. Regional chemotherapy administration represents a means to generate increased drug exposure in the region where the tumor resides, while maintaining a lower drug exposure at the level of dose-limiting normal host tissues elsewhere in the body. Thus, even in circumstances where systemically administered chemotherapy is relatively ineffective, regional chemotherapy may improve the likelihood of response by the generation of much greater drug exposure. With sufficient regional selectivity, dose-limiting toxicity should be manifested by the normal tissues of the region infused and not by tissues elsewhere in the body. In this regard, regional chemotherapy has similarities to radiation therapy, but may be more selective in those situations where tumor and normal tissue in the treated region differ significantly in intrinsic drug sensitivity and blood supply.

Keywords

Tumor Nodule Total Body Clearance Regional Chemotherapy Starch Microsphere Regional Advantage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. W. Eckman, C. S. Patlak, and J. D. Fenstermacher, A critical evaluation of principles governing the advantages of intraarterial infusions, J. Pharmacokinet Biopharm2:257–285,(19741.Google Scholar
  2. 2.
    H. S. Ga Chen, and J. F. Gross, Intra-arterial infusion of anti-cancer drugs: Theoretic aspects of drug delivery and review of responses, Cancer Treat Rep64: 31–40, (1980).Google Scholar
  3. 3.
    J, M. Collins, and R. L. Dedrick, Pharmacokinetics of anticancer drugs, in: Pharmacologic Principles of Cancer Treatment, Chabner B, ed., W. B. Saunders Co., Philadelphia, (1982).Google Scholar
  4. 4.
    B. A. Warren, The vascular morphology of tumors, in: Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors, Peterson HI, ed., CRC Press, Inc., Florida, (1979).Google Scholar
  5. 5.
    J. W. Gyves, H. A. Ziessman, W. D. Ensminger, J. H. Thrall, J. E. Niederhuber, J. W. Keyes, Jr., and S. Walker, Definition of hepatic tumor microcirculation (SPECT), J Nucl Med. 25: 972– 977 (1984).Google Scholar
  6. 6.
    H. A. Ziessman, J. H. Thrall, J. W. Gyves, W. D. Ensminger, J. E. Niederhuber, M. Tuscan and S. Walker, Quantitative hepatic arterial perfusion scintigraphy and starch microspheres in cancer chemotherapy. J Nucl Med24: 871–875 (1983).Google Scholar
  7. 7.
    S. Dakhil, W. D. Ensminger, K. Cho, J. Niederhuber, K. Doan, and R. Wheeler, Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer50: 631–635 (1982).CrossRefGoogle Scholar
  8. 8.
    J. W. Gyves, W. D. Ensminger, D. Vanharken, J. Niederhuber, P. Stetson, S. Walker, Improved regional selectivity of hepatic arterial mitomycin by starch microspheres, Clin Pharmacol Ther34: 259–265 (1983).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John W. Gyves
    • 1
  1. 1.University of MichiganAnn ArborUSA

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