Abstract
Exposure to psychoactive drugs early in life may produce long-term alterations in the behavior of an organism resulting from subtle changes in the ultrastructure of the nervous system even in the absence of gross structural malformations. Chronic administration of neuroleptic drugs to laboratory animals early in ontogeny appears to induce such neurobehavioral teratogenic effects without precipitating gross congenital malformations. Although it appears from the clinical literature that neuroleptics do not produce gross congenital malformations, the potential neurobehavioral teratogenic effects of these substances on human offspring have not been systematically assessed in clinical populations (Goldberg & DiMascio, 1978). Yet, neuroleptics are frequently prescribed as antipsychotics and are even used as antiemetics in obstetrics (Goldberg & DiMascio, 1978).
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Spear, L.P., Scalzo, F.M. (1986). Behavioral, Psychopharmacological, and Neurochemical Effects of Chronic Neuroleptic Treatment during Development. In: Riley, E.P., Vorhees, C.V. (eds) Handbook of Behavioral Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2189-7_8
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DOI: https://doi.org/10.1007/978-1-4613-2189-7_8
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