Principles of Behavioral Teratology

  • Charles V. Vorhees


James Wilson has undoubtedly done more to describe the general principles and mechanisms of teratogenic response than anyone else. These principles were most recently presented in 1977 (Wilson, 1977). Here, the principles of behavioral teratogenic response will be defined as an extension of Wilson’s concepts. Refinement and updating of our previous description of the principles of behavioral teratogenesis (Vorhees & Butcher, 1982) have also been undertaken below.


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  1. Abel, E. L. Fetal alcohol syndrome: Behavioral teratology. Psychological Bulletin, 1980, 87, 29–50.PubMedCrossRefGoogle Scholar
  2. Abel, E. L. Behavioral teratology of alcohol. Psychological Bulletin, 1981, 90, 564–581.PubMedCrossRefGoogle Scholar
  3. Adams, P. M., Fabricant, J. D., & Legator, M. S. Cyclophosphamide-induced spermatogenic effects detected in the F! generation by behavioral testing. Science, 1981, 211, 80–82.PubMedCrossRefGoogle Scholar
  4. Ballard, J. L., Holroyde, J., Tsang, R. C., Chan, G., Sutherland, J. M., & Knowles, H. C. High malformation rates and decreased mortality in infants of diabetic mothers managed after the first trimester of pregnancy (1956–1978). American Journal of Obstetrics and Gynecology, 1984, 148, 1111–1118.PubMedGoogle Scholar
  5. Brent, R. L. Review of Developmental Toxicology, edited by K. Snell. American Journal of Diseases of Children, 1983, 137, 511–512.Google Scholar
  6. Butcher, R. E. Learning impairment associated with maternal phenylketonuria in rats. Nature, 1970, 226, 555– 556.PubMedCrossRefGoogle Scholar
  7. Butcher, R. E., & Vorhees, C. V. A preliminary test battery for the investigation of the behavioral teratology of selected psychotropic drugs. Neurobehavioral Toxicology, 1979, 1 (Suppl. 1), 207–212.PubMedGoogle Scholar
  8. Butcher, R. E., & Vorhees, C. V. Behavioral testing in rodents given food additives. In L. D. Stegink & L. J. Filer (Eds.), Aspartame: Physiology and biochemistry. New York: Marcel Dekker, 1984.Google Scholar
  9. Butcher, R. E., Brunner, R. L., Roth, T., & Kimmel, C. A. A learning impairment associated with maternal hypervitaminosis-A in rats. Life Sciences, 1972, 11, 141–145.CrossRefGoogle Scholar
  10. Butcher, R. E., Vorhees, C. V., & Kimmel, C. A. Learning impairment from maternal salicylate treatment in rats. Nature New Biology, 1972, 236, 211–212.PubMedCrossRefGoogle Scholar
  11. Butcher, R. E., Scott, W. J., Kazmaier, K., & Ritter, E. J. Postnatal effects in rats of prenatal treament with hydroxyurea. Teratology, 1973, 7, 161–166.PubMedCrossRefGoogle Scholar
  12. Butcher, R. E., Hawver, K., Burbacher, T., & Scott, W. Behavioral effects from antenatal exposure to teratogens. In N. R. Ellis (Ed.), Aberrant development in infancy: Human and animal studies. Hillsdale, NJ: Erlbaum, 1975.Google Scholar
  13. Butcher, R. E., Hawver, K., Kazmaier, K., & Scott, W. Postnatal behavioral effects from prenatal exposure to teratogens. In P. L. Morselli, S. Garattini, & F. Sereni (Eds.), Basic and therapeutic aspects of perinatal pharmacology. New York: Raven Press, 1975.Google Scholar
  14. Clarren, S. K., & Smith, D. W. The fetal alcohol syndrome. New England Journal of Medicine, 1978, 298, 1063–1067.PubMedCrossRefGoogle Scholar
  15. Davenport, J. W., & Dorcey, T. P. Hypothyroidism: Learning deficit induced in rats by early exposure to thiouracil. Hormones and Behavior, 1972, 3, 97–112.PubMedCrossRefGoogle Scholar
  16. Edwards, M. J., Gray, C. H., & Beatson, J. Retardation of brain growth of guinea pigs by hyperthermia: Effect of varying intervals between successive exposures. Teratology, 1984, 29, 305–312.PubMedCrossRefGoogle Scholar
  17. Elmazar, M. M. A., & Sullivan, F. M. Effect of prenatal phenytoin administration on postnatal development of the rat: A behavioral teratology study. Teratology, 1981, 24, 115–124.PubMedCrossRefGoogle Scholar
  18. Finger, S., & Stein, D. G. Brain damage and recovery: Research and clinical perspectives. New York: Academic Press, 1982.Google Scholar
  19. Friedler, G. Effects of pregestational morphine administration to mice on behavior of their offspring. Pharmacologist, 1974, 76, 203.Google Scholar
  20. Ginsburg, B. E., Yanai, J., & Sze, P. Y. A developmental genetic study of the effects of alcohol consumed by parent mice on the behavior and development of their offspring. In Proceedings of the Fourth Annual Alcoholism Conference of the National Institute on Alcohol Abuse and Alcoholism. Washington, DC: U.S. Department of Health, Education and Welfare, 1975.Google Scholar
  21. Haddad, R. K., Rabe, A., & Dumas, R. Comparison of effects of methylazoxymethanol acetate on brain development in different species. Federation Proceedings, 1972, 31, 1520–1523.PubMedGoogle Scholar
  22. Haddad, R., Rabe, A., & Dumas, R. Neuroteratogenicity of methylazoxymethanol acetate: Behavioral deficits of ferrets with transplacentally induced lissencephaly. Neurotoxicology, 1979, 1, 171–189.Google Scholar
  23. Herman, C. S., Kirchner, G. L., Streissguth, A. P., & Little, R. E. Vigilance paradigm for preschool children used to relate vigilance behavior to IQ and prenatal exposure to alcohol. Perceptual and Motor Skills, 1980, 50, 863–867.PubMedCrossRefGoogle Scholar
  24. Hutchings, D. E. Behavioral teratology: Embryopathic and behavioral effects of drugs during pregnancy. In G. Gottlieb (Ed.), Studies on the development of behavior and the nervous system: Early influences, Vol. 4. New York: Academic Press, 1978.Google Scholar
  25. Hutchings, D. E., & Gaston, J. The effects of vitamin A excess administered during the mid-fetal period and learning and development in rat offspring. Developmental Psychobiology, 1974, 7 225–233.PubMedCrossRefGoogle Scholar
  26. Hutchings, D. E., Gibbon, J., & Kaufman, M. A. Maternal vitamin A excess during the early fetal period: Effects on learning and development in the offspring. Developmental Psychobiology, 1973, 6, 445–457.PubMedCrossRefGoogle Scholar
  27. Jacobson, J. L., Jacobson, S. W., Fein, G. G., Schwartz, P. M., & Dowler, J. K. Prenatal exposure to an environmental toxin: A test of the multiple effects model. Developmental Psychology, 1984, 20, 523–532.CrossRefGoogle Scholar
  28. Joffe, J. M. Prenatal determinants of behaviour. Oxford: Pergamon Press, 1969.Google Scholar
  29. Kalter, H., & Warkany, J. Congenital manformations: Etiologic factors and their role in prevention. New England Journal of Medicine, 1983, 308, 424–431, 491–497.Google Scholar
  30. Kellogg, C., Tervo, D., Ison, J., Parisi, T., & Miller, R. K. Prenatal exposure to diazepam alters behavioral development in rats. Science, 1980, 207, 205–207.PubMedCrossRefGoogle Scholar
  31. Kellogg, C., Ison, J. R., & Miller, R. K. Prenatal diazepam exposure: Effects on auditory temporal resolution in rats. Psychopharmacology, 1983, 79, 332–337.PubMedCrossRefGoogle Scholar
  32. Khera, K. S. Maternal toxicity—A possible factor in fetal malformations in mice. Teratology, 1984, 29, 411– 416.CrossRefGoogle Scholar
  33. Khera, K. S. Maternal toxicity: A possible etiological factor in embryofetal deaths and fetal malformations of rodent-rabbit species. Teratology, 1985, J7, 129–153.CrossRefGoogle Scholar
  34. Lou, H. C. Developmental neurology. New York: Raven Press, 1982.Google Scholar
  35. Miller, R. K., Ng, W. W., & Levin, A. A. The placenta: Relevance to toxicology. In T. Clarkson, G. Nordberg, & P. Sager (Eds.), Reproductive and developmental toxicity of metals. New York: Plenum Press, 1983.Google Scholar
  36. Nelson, B. K. Dose/effect relationships in developmental neurotoxicology. Neurobehavioral Toxicology and Teratology, 1981, 3, 255.PubMedGoogle Scholar
  37. Osborne, G. L., Caul, W. F., & Fernandez, K. Behavioral effects of prenatal ethanol exposure and differential early experience in rats. Pharmacol. Biochem. Behav., 1980, 12, 393–401.PubMedCrossRefGoogle Scholar
  38. Rodier, P. M. Correlations between prenatally-induced alternations in CNS cell populations and postnatal function. Teratology, 1977, 16, 235–246.PubMedCrossRefGoogle Scholar
  39. Rodier, P. M. Chronology of neuron development: Animal studies and their clinical implications. Developmental Medicine and Child Neurology, 1980, 22, 525–545.Google Scholar
  40. Rodier, P. M., & Reynolds, S. S. Morphological correlates of behavioral abnormalities in experimental congenital brain damage. Experimental Neurology, 1977, 57, 81–93.PubMedCrossRefGoogle Scholar
  41. Rodier, P. M., Reynolds, S. S., & Roberts, W. N. Behavioral consequences of inteference with CNS development in the early fetal period. Teratology, 1979, 19, 327–336.PubMedCrossRefGoogle Scholar
  42. Sever, J. L. Maternal infections. In C. C. Brown (Ed.), Childhood learning disabilities and prenatal risk. New York: Johnson & Johnson, 1983.Google Scholar
  43. Simmons, R. D., Kellogg, C. K., & Miller, R. K. Prenatal diazepam exposure in rats: Long-lasting, receptor- mediated effects on hypothalamic norepinephrine-containing neurons. Brain Research, 1984, 293, 73–83.PubMedCrossRefGoogle Scholar
  44. Spyker, J. M., Sparber, S. B., & Goldberg, A. M. Subtle consequences of methylmercury exposure: Behavioral deviations in offspring of treated mothers. Science, 1972, 177, 621–623.PubMedCrossRefGoogle Scholar
  45. Streissguth, A. P., Martin, D. C., Martin, J. C., & Barr, H. M. The Seattle longitudinal prospective study on alcohol and pregnancy. Neurobehavioral Toxicology and Teratology, 1981, 3, 223–233.PubMedGoogle Scholar
  46. Streissguth, A. P., Barr, H. M., & Martin, D. C. Maternal alcohol use and neonatal habituation assessed with the Brazelton scale. Child Development, 1983, 54, 1109–1118.PubMedCrossRefGoogle Scholar
  47. Vorhees, C. V. Some behavioral effects of maternal hypervitaminosis A in rats. Teratology, 1974, 10, 269–274.CrossRefGoogle Scholar
  48. Vorhees, C. V. Effects of prenatal naloxone exposure on postnatal behavioral development in rats. Neurobehavioral Toxicology and Teratology, 1981, 3, 295–301.PubMedGoogle Scholar
  49. Vorhees, C. V. Fetal anticonvulsant syndrome in rats: Dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione, and phenobarbital exposure on the structural and functional development of the offspring. Journal of Pharmacology and Experimental Therapeutics, 1983, 227, 274–287.Google Scholar
  50. Vorhees, C. V. Fetal anticonvulsant syndrome in rats: Effects on postnatal behavior and brain amino acid content. Neurobehavioral Toxicology and Teratology, 1985, 7, 471–482.Google Scholar
  51. Vorhees, C. V., & Butcher, R. E. Behavioral teratogenicity. In K. Snell (Ed.), Developmental toxicology. New York: Praeger, 1982.Google Scholar
  52. Vorhees, C. V., Brunner, R. L., McDaniel, C. R., & Butcher, R. E. The relationship of gestational age to vitamin A induced postnatal dysfunction. Teratology, 1978, 17, 271–276.PubMedCrossRefGoogle Scholar
  53. Vorhees, C. V., Brunner, R. L., & Butcher, R. E. Psychotropic drugs as behavioral teratogens. Science, 1979, 205, 1220–1225.PubMedCrossRefGoogle Scholar
  54. Vorhees, C. V., Klein, K. L., & Scott, W. J. Aspirin-induced psychoteratogenesis in rats as a function of embryonic age. Teratogenesis, Carcinogenesis and Mutagenesis, 1982, 2, 77–84.CrossRefGoogle Scholar
  55. Wilson, J. G. Environment and birth defects. New York: Academic Press, 1973.Google Scholar
  56. Wilson, J. G. Current status of teratology: General principles and mechanisms derived from animal studies. In J. G. Wilson & F. C. Fraser (Eds.), Handbook of teratology, general principles and etiology, Vol. 1. New York: Plenum Press, 1977.Google Scholar
  57. Zimmerman, E. F. Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development. American Journal of Mental Deficiency, 1984, 88, 548–558.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Charles V. Vorhees
    • 1
  1. 1.Institute for Developmental Research, Children’s Hospital Research Foundation, and Department of PediatricsUniversity of Cincinnati College of MedicineCincinnatiUSA

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